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Applied Genetics Lab
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The lab uses gene manipulation techniques to investigate how ovaries and sperm are formed.

AboutAbout the lab
Exploring gene function through eggs and sperm
The Applied Genetics Lab studies how the ovaries of mammals develop and how sperm are produced.
Using techniques from reproductive engineering and developmental engineering, the lab introduces genes into eggs, sperm, tissues, and whole animals to examine gene function and its regulation.
This approach of deliberately altering genes to investigate their function is called reverse genetics.
Undergraduate students from the Major in Animal Life Sciences and the Major in Veterinary Medical Sciences, and graduate students from the Department of Animal Resource Sciences, belong to the lab.
Key terms
- Reverse genetics
- A method of deliberately altering a gene to find out what function that gene performs
- Meiosis
- A special type of cell division that occurs when eggs and sperm are produced, in which the number of chromosomes is halved
- Spermatogonia
- Undifferentiated cells in the testis that give rise to sperm
NewsLab news
A doctoral student received the Dean's Award of the Graduate School, and a master's student received the Department Award
A student received the Department Award
Paper by Prof. Sugiura and colleagues published in Molecular Reproduction and Development
ResearchResearch themes
Using reverse genetics, in which genes are introduced into mammalian eggs, sperm, tissues, and whole animals through reproductive engineering and developmental engineering techniques, the lab studies gene function and its regulation. Its work covers ovarian development and the regulation of ovarian function, as well as the mechanisms of meiosis and spermatogenesis.
*Illustrative imageMechanisms of ovarian development and function
Using mice and pigs as models, the lab studies the development and regulation of ovarian function at the levels of the whole animal, cells, and tissues. It also investigates the interactions between oocytes and their surrounding cells, and the age-related decline in fertility.
*Illustrative imageMeiosis and spermatogenesis
The lab studies how undifferentiated spermatogonia in the testis are regulated as they differentiate into spermatocytes that undergo meiosis, as well as the mechanisms of spermatogenesis. It also investigates cell transplantation into the testis and the age-related decline in spermatogenesis.
MembersFaculty
The members of the Applied Genetics Lab consist of faculty, special research students, and doctoral, master's, and undergraduate students.As of 2026
- ProfessorSugiura KojiPublications ↗
- Assistant Professorえんどう
つと Publications ↗む Tsutomu Endo
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “GFP Mice 01” Ingrid Moen, Charlotte Jevne, Jian Wang, Karl-Henning Kalland, Martha Chekenya, Lars A Akslen, Linda Sleire, Per Ø Enger / CC BY 2.0 (cropped)
- Mechanisms of ovarian development and function: “Ovarian cortex in a rhesus monkey” Tulemo / CC BY-SA 4.0 (cropped)
- Meiosis and spermatogenesis: “Seminiferous tubule and sperm” Nephron / CC BY-SA 3.0 (cropped)
- Related lab (産業技術総合研究所): “Brainbow (Smith 2007)” Stephen J Smith / CC BY 3.0 (cropped)
- Related lab (細胞生化学研究室): “Fetus and placenta - journal.pbio.0060312.g001” Wei Hsu, Shang-Yi Chiu / CC BY 2.5 (cropped)
- Related lab (放射
線動物科学研究室): “Individually cage for lab mice” Karol Głąb (Karol007) / CC BY-SA 3.0 (cropped) - Related lab (応用免疫学研究室): “Leishmania major promastigotes” Abanima (ru.wikipedia) / CC BY-SA 3.0 (cropped)
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