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Clinical Pharmacotherapy Lab
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A drug therapy lab that studies how drugs work and cause side effects using patient data.
AboutAbout the lab
Building the ground rules for using drugs, from patient data.
The Clinical Pharmacotherapy Lab studies how drugs work and what side effects they cause using patient data, and explores how to use them rationally.
The lab's research is introduced as "Research Activities" on the website of the Department of Pharmacy, Kyushu University Hospital.
Because a drug that is misused becomes a "poison" with nothing but side effects, the lab collects and carefully examines patient data and builds up evidence for the most rational way to use drugs for the next patient.
The research covers a wide range, and the lab states that there are opportunities for everyone to take the leading role.
Key terms
- Biomarker
- A molecular biological indicator in the body that offers clues about a disease or the effects of a drug. In this research, the lab searches for ones in urine.
- Acute Kidney Injury
- A condition in which kidney function drops suddenly. This lab deals with cases caused by drugs used for diagnosis or treatment.
- Immunosuppressant
- A drug essential in transplantation. Sensitivity is known to vary greatly between patients.
ResearchResearch themes
Based on the idea that a drug becomes a true "medicine" only when it is used skillfully, the lab uses data obtained from patients to build up evidence for rational use of drugs for the next patient. It works on a wide range of themes, including searching for indicators of drug efficacy and toxicity, the mechanisms behind side effects, and dosing design using genetic information.
*Illustrative imageBiomarkers of Drug Efficacy and Toxicity
The lab searches for urinary biomarkers that can detect, quickly and accurately, the nephrotoxicity caused by drugs excreted by the kidneys and by drugs that accumulate at high concentrations in the kidneys. The research is conducted with clinical use in mind.
*Illustrative imageMechanisms and Countermeasures of Drug Toxicity
The lab investigates acute kidney injury caused by anticancer drugs and antibiotics, from the molecular level to the animal level, aiming to clarify how it arises and to establish effective prevention. For peripheral neuropathy caused by anticancer drugs, it creates model rats that allow evaluation and explores the mechanisms and countermeasures.
*Illustrative imageIndividualized Dosing Design Using Genetic Information
Immunosuppressants used in transplantation show large individual differences in sensitivity from patient to patient. The lab aims to establish a new personalized immunosuppressive therapy that adds genetic information to general clinical information, with a focus on clinical research.
*Illustrative imageFactors Behind Individual Differences in Efficacy and Side Effects
Starting from the premise that drug efficacy and side effects differ from patient to patient, the lab searches for conditions that can explain this link. It collects clinical information from patients treated with drugs, analyzes it statistically, and feeds any noteworthy findings back to clinical practice.
MembersFaculty
- ProfessorMayako Uchida
- Associate ProfessorTakehiro Kawashiri
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Bio-inspired hybrid multifunctional drug delivery system (cropped)” Joachim Delasoie, Philippe Schiel, Sandra Vojnovic, Jasmina Nikodinovic-Runic and Fabio Zobi / CC BY-SA 4.0 (cropped)
- Biomarkers of Drug Efficacy and Toxicity: “Mass Spectrometry Machine (NIH BioArt 286)” Courtesy of NIAID Ryan Kissinger / Public domain (cropped)
- Mechanisms and Countermeasures of Drug Toxicity: “Acetominophen toxicity in the liver - portal area injury with necrotic zone apparent” Case contributed by Dr. Linda Ferrell, UCSF Department of Pathology. / Public domain (cropped)
- Individualized Dosing Design Using Genetic Information: “Farmakogenoomika rakendamise algatused” Kristi Krebs / CC BY-SA 4.0 (cropped)
- Factors Behind Individual Differences in Efficacy and Side Effects: “Tablets pills medicine medical waste” Pöllö / CC BY 3.0 (cropped)
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（連携講座） ): “Tula Pharmaceutical Factory 08” Пресс-центр Правительства Тульской области. / CC BY 4.0 (cropped) - Related lab (臨床育薬学分野): “Pharmacie in Paulista Avenue” Wilfredor / CC BY-SA 4.0 (cropped)
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