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Precision Medicine Research Center Lab
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A lab exploring cancer care suited to each patient based on genomic information.
AboutAbout the lab
Aiming for the cancer precision medicine best suited to each patient
The Division of Precision Medicine studies precision medicine, which uses objective data such as genomic information and test results to find the most suitable treatments and preventive measures for each patient.
Its scope spans all of medicine, but the lab is starting by building the foundations for clinical practice, education, and research in "cancer precision medicine."
The lab pursues three themes: elucidating the diversity of cancer and developing new treatments to overcome it; establishing cancer prevention methods based on individual genomic information; and building a clinical system in which new cancer drugs can be used.
On the lab's website, it is introduced under the name "Division of Precision Medicine."
Key terms
- Precision medicine
- Medical care that provides the treatment and prevention best suited to each patient, based on various data such as genomic information
- Gene panel testing
- A test that analyzes many cancer-related genes at once to examine the genetic abnormalities in cancer tissue
- CRISPR/Cas9
- A gene editing technology. In this lab, it is used as a method to comprehensively search for therapeutic targets in cancer
- Hematopoietic stem cell
- A cell that gives rise to all blood cells and supports blood formation through self-renewal and differentiation
NewsLab news
A paper on therapeutic targets in TP53-mutated acute myeloid leukemia was published in Blood
A paper on the DDX19 gene, which affects sensitivity to the XPO1 inhibitor selinexor, was published in Leukemia
A paper examining the relationship between steroid resistance in leukemia cells and the mTOR pathway was published in Blood Neoplasia
ResearchResearch themes
The lab works to build the foundations of precision cancer medicine, which provides the cancer prevention and treatment best suited to each patient based on various data such as genomic information. From both clinical and research perspectives, it investigates genetic abnormalities at the cell and individual level that make cancers harder to treat, and explores ways to overcome them.
*Illustrative imagePrecision cancer medicine and gene panel testing
The lab developed DISCAVar, a gene panel test specialized for blood cancers, in collaboration with the Hematology Laboratory of the First Department of Internal Medicine at Kyushu University and the Department of Gene and Cell Therapy at Kyushu University Hospital. It conducts research on precision cancer medicine at Kyushu University Hospital and affiliated facilities.
*Illustrative imageFinding therapeutic targets with CRISPR/Cas9
This research uses CRISPR/Cas9 gene editing technology to comprehensively identify therapeutic targets in cancer. The lab performs genome-wide screening in leukemia cell lines with different genetic backgrounds and under conditions with various drugs added, and is developing new treatments and drugs for refractory leukemia.
*Illustrative imageSingle-cell research on cancer
Because the cancer in a patient's body is diverse from cell to cell, the lab uses analyses that examine the characteristics of individual cells. Together with the First Department of Internal Medicine and the Department of Gene and Cell Therapy at Kyushu University, it seeks to elucidate immune reconstitution after hematopoietic stem cell transplantation and the mechanisms of leukemia relapse.
*Illustrative imageMechanisms controlling blood cell differentiation
The lab aims to elucidate the molecular mechanisms that control the differentiation and proliferation of blood cells, and to apply them to the treatment of blood diseases such as blood cancers, as well as connective tissue diseases, chronic inflammatory diseases, and cardiovascular diseases. It also studies how the transcription factor LRF controls blood cell differentiation.
MembersFaculty
The members of the Division of Precision Medicine consist of faculty, collaborating researchers, and graduate students in the doctoral and master's programs.As of 2026
- ProfessorTakahiro Maeda
- Assistant ProfessorShigeki Hirabayashi
- Assistant ProfessorYuichiro Semba
- Assistant ProfessorKiyoko Miyata
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “DNBSEQ-G50” RPSkokie / CC BY-SA 4.0 (cropped)
- Precision cancer medicine and gene panel testing: “Next generation sequencing slide” Bainscou / CC BY 3.0 (cropped)
- Finding therapeutic targets with CRISPR/Cas9: “CRISPR Cas9 technology” Elena I Leonova / CC BY 4.0 (cropped)
- Single-cell research on cancer: “Müürlooga (Arabidopsis thaliana) lehekarv (trihhoom) 311 0804” Heiti Paves / CC BY-SA 3.0 (cropped)
- Mechanisms controlling blood cell differentiation: “Myeloblast” El*Falaf / CC BY-SA 4.0 (cropped)
- Related lab (Neuroanatomy Lab): “Sagittal brain slice, UB Museum of Neuroanatomy, Buffalo, New York” Caldwbr / CC BY-SA 4.0 (cropped)
- Related lab (Developmental and Regenerative Medicine Lab): “Mouse embryo ( )” Pazit Polak from Basel, Switzerland / CC BY 2.0 (cropped)
- Related lab (Medical Chemistry Lab): “DNA Structure+Key+Labelled.pn NoBB” Zephyris / CC BY-SA 3.0 (cropped)
- Related lab (Biochemistry Lab): “A Pathway to Protocells on Titan – Animations (SVS -Cell-Membrane-Thumbnail)” NASA's Scientific Visualization Studio - NASA Goddard / Public domain (cropped)
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