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Medical Chemistry Lab
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A lab that aims to understand living systems from the standpoint of genome science.
AboutAbout the lab
Aiming to understand living systems through comprehensiveness and quantitative measurement
The Medical Chemistry Lab develops its own strategies from the standpoint of genome science and conducts research aimed at contributing to the understanding of living systems.
With comprehensiveness and quantitative measurement as its keywords, the lab advances its research on the foundation of developing original technologies.
Using budding yeast, the lab investigates gene expression and protein-protein interactions, and it also works on technologies for examining DNA methylation status across the entire genome.
The lab wants to be a place that trains researchers with both comprehensive measurement and data analysis skills, and it welcomes students of any background.
Key terms
- Budding yeast
- The yeast this lab uses as a model organism. It is used to analyze gene expression and protein interactions
- Non-coding RNA
- RNA that is not translated into protein. This lab discovered many of them through large-scale analysis of full-length cDNA
- Ubiquitination
- A post-translational modification in which a protein called ubiquitin is attached to another protein. It is involved in regulating a wide range of cellular functions
ResearchResearch themes
With comprehensiveness and quantitative measurement as its keywords, the lab builds on the development of its own technologies and aims to contribute to the understanding of living systems. It studies genome expression, protein networks, and the DNA methylome. The papers cited on the research page date from around 2012, and the description on the lab website reflects that period.
*Illustrative imageGenome expression and non-coding RNA
Using budding yeast, the lab examines the whole picture of transcription through comprehensive measurements with next-generation sequencers. By studying the frequency of transcriptional noise in non-coding RNAs, expression during meiosis, and comparisons with closely related species, it tries to draw a new picture of genome expression.
*Illustrative imageProtein interaction networks
Using its own proteomics technology based on isotope labeling and mass spectrometry, the lab quantitatively investigates interactions between proteins. By clarifying which ubiquitination enzymes correspond to which substrates, it aims to elucidate the ubiquitination network.
*Illustrative imageGenome-wide analysis of DNA methylation
Using next-generation sequencers, the lab is developing technology to examine DNA methylation status across the entire genome at single-base resolution. With this technology, it is opening a breakthrough in epigenome analysis of stem cells and early embryos, and it hopes to approach the elucidation of molecular mechanisms through new rules of methylation and demethylation.
MembersFaculty
The members of the Medical Chemistry Lab consist of faculty members, graduate students, and technical staff.
- ProfessorTakashi Ito
- Associate ProfessorFumihito Miura
- Assistant ProfessorSatoru Okada
- Assistant ProfessorHiroaki Takei
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “DNA Structure+Key+Labelled.pn NoBB” Zephyris / CC BY-SA 3.0 (cropped)
- Genome expression and non-coding RNA: “Gene expression control” ArneLH / CC BY-SA 3.0 (cropped)
- Protein interaction networks: “Protein–protein interaction network and GO enrichment visualization generated by the author using STRING v12.0 from a curated human immune gene set (FG-001)” BioMedia1091 / CC BY 4.0 (cropped)
- Genome-wide analysis of DNA methylation: “RNA-directed DNA Methylation (RdDM)” A. Koetz / CC BY-SA 4.0 (cropped)
- Related lab (神経解剖学): “Sagittal brain slice, UB Museum of Neuroanatomy, Buffalo, New York” Caldwbr / CC BY-SA 4.0 (cropped)
- Related lab (発生再生医学): “Mouse embryo ( )” Pazit Polak from Basel, Switzerland / CC BY 2.0 (cropped)
- Related lab (生化学): “A Pathway to Protocells on Titan – Animations (SVS -Cell-Membrane-Thumbnail)” NASA's Scientific Visualization Studio - NASA Goddard / Public domain (cropped)
- Related lab (系統解剖学): “Giant Puffer fish skin pattern” Chiswick Chap / CC BY-SA 3.0 (cropped)
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