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Developmental and Regenerative Medicine Lab
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A lab that explores how the body is built, using early mouse embryos.
AboutAbout the lab
Exploring how an individual forms from a fertilized egg
The Developmental and Regenerative Medicine Lab uses mice to study how a complex individual is built from a single fertilized egg.
After the embryo implants in the uterus, the body axes (anterior–posterior, dorsal–ventral, and left–right) are established, and the mesoderm moves anteriorly to form the precursor of the heart.
The lab aims to clarify the molecular mechanisms that control these early developmental events through genetic analysis, imaging, and other approaches.
Disruptions in early developmental events are also closely linked to infertility and congenital anomalies in humans.
Key terms
- Body axis
- The axes that serve as references for determining the anterior–posterior, dorsal–ventral, and left–right directions of the embryo
- Left–right axis
- The axis that distinguishes the left and right sides of the embryo. It is the basis for organs taking left–right asymmetric shapes
- Mesoderm
- One of the cell layers arising from the primitive streak of the embryo. It migrates and forms structures such as the precursor of the heart
NewsLab news
Press release on the discovery of how the cardiac conduction system forms in the correct position
An Assistant Professor won the top prize at the pitch contest FBCAP Innovation Event
An Assistant Professor and a student won the BRAVE Tech Award
ResearchResearch themes
Using early mouse embryos, the lab studies how the body axes are established and how the precursor of the heart is formed. It aims to clarify the molecular mechanisms that control these processes through genetic analysis, imaging, and other approaches.
*Illustrative imageLeft–right axis formation and congenital anomalies
Although the body looks bilaterally symmetric on the outside, the internal organs are asymmetric. The lab investigates how the left–right axis forms in mouse embryos and related congenital anomalies, and also analyzes the effects of diabetes on left–right axis formation in embryos of diabetic mice.
*Illustrative imageAnterior–posterior axis formation
A group of cells at the distal end of the mouse embryo migrates in one direction, and the side it moves toward becomes the anterior. The lab investigates how the anterior–posterior axis is established, including the relationship between the direction of this cell migration and biases in gene expression.
*Illustrative imageMorphogenesis of the inner ear
The lab studies how the complex shape of the inner ear is formed during development. It found that Wnt signaling fades away from the lateral side in the dorsal region as well, and that this suppression is required for formation of the semicircular canals.
MembersFaculty
The members of the Developmental and Regenerative Medicine Lab consist of faculty members, doctoral students, and technical staff.As of 2026
- ProfessorChikara Meno
- Assistant ProfessorKeiko Kitajima
- Assistant ProfessorTakenobu Nii
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Mouse embryo ( )” Pazit Polak from Basel, Switzerland / CC BY 2.0 (cropped)
- Left–right axis formation and congenital anomalies: “Situs inversus - Mirrored heart and lungs” The original uploader was Angela at English Wikipedia. / Public domain (cropped)
- Anterior–posterior axis formation: “Aves Neural tube and somites in chick embryo” Prof. R. Bellairs / CC BY 4.0 (cropped)
- Morphogenesis of the inner ear: “Global-visualization-of-the-inner-ear-and-zoom-on-the-3-canals-angular-sensors” P. Selva, J. Morlier, Y. Gourinat / CC BY 4.0 (cropped)
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