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Center for Cohort Study Environmental Epidemiology Lab
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A lab that studies complications in preterm and low-birth-weight infants with the aim of advancing perinatal care.
AboutAbout the lab
Advancing perinatal care through NICU clinical research.
The Environmental Epidemiology lab conducts clinical research on neonates with complications, such as preterm and low-birth-weight infants.
Using a multicenter clinical research system that prospectively follows the treatment course of neonates admitted to the NICU, the lab aims to contribute to the advancement of evidence-based perinatal care.
The lab works on research into complications related to oxidative injury in preterm infants, and has also studied thrombophilia related to complications in very low birth weight infants.
The lab is part of the Advanced Public Health Division of the Center for Cohort Study at the Faculty of Medical Sciences.
Key terms
- NICU
- Neonatal intensive care unit. Neonates with complications, including preterm and low-birth-weight infants, are admitted and treated there
- Thrombophilia
- A predisposition that, together with environmental factors, influences the formation of blood clots. In this lab, thrombophilia in the neonatal period was comprehensively examined with a genetic panel test
- Oxidative injury
- Injury involving reactive oxygen species and oxidized lipids. In preterm infants, it is linked to complications such as retinopathy of prematurity and bronchopulmonary dysplasia
ResearchResearch themes
Neonates with complications are admitted to the NICU, so their treatment course can be followed prospectively alongside clinical care. Through multicenter clinical research and studies exploring the mechanisms of complications in preterm and very low birth weight infants, the lab aims to advance perinatal care.
*Illustrative imageMulticenter Clinical Research in the NICU
Using a multicenter clinical research system that follows the treatment course of neonates admitted to the NICU, the lab has reported the results of observational studies. It now aims to carry out interventional studies. The lab is also building clinical care systems for the diverse and rare genetic diseases that develop in the neonatal period, and developing new diagnostics and treatments.
*Illustrative imageOxidative Injury and Complications in Preterm Infants
In preterm infants, the lab measures reactive oxygen species in neutrophils and oxidized lipids using a device that gives fast results from a very small sample. It clarifies how these values change during the neonatal period and how they relate to complications involving oxidative injury, and explores whether they could be used as endpoints in clinical trials.
*Illustrative imageComplications and Thrombophilia in Very Low Birth Weight Infants
The major complications of very low birth weight infants involve angiogenesis and a tendency toward thrombosis. The lab conducted research to find thrombophilia factors that affect these complications, using a genetic panel test that comprehensively examines thrombophilia in the neonatal period. From a registry of early-onset thrombosis, it showed that protein C deficiency is involved in thrombophilia in the neonatal period.
MembersFaculty
- Associate ProfessorMasayuki Ochiai
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Mcmaster NICU infant 6978” Peter K Burian / CC BY-SA 4.0 (cropped)
- Multicenter Clinical Research in the NICU: “Infant-Incubator-wBaby-1978-USA” Evan-Amos / Public domain (cropped)
- Oxidative Injury and Complications in Preterm Infants: “Neutrophil 1” Dr. Roshan Nasimudeen / CC BY-SA 3.0 (cropped)
- Complications and Thrombophilia in Very Low Birth Weight Infants: “Cardiovascular system - From atheroma to thrombosis 2 -- Smart-Servier” Laboratoires Servier / CC BY-SA 3.0 (cropped)
- Related lab (Neuroanatomy Lab): “Sagittal brain slice, UB Museum of Neuroanatomy, Buffalo, New York” Caldwbr / CC BY-SA 4.0 (cropped)
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