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Center for Human Disease Models, Pathogen Infection Animal Models Lab
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The lab develops disease-resistant animals and disease model animals to explore how diseases arise.
AboutAbout the lab
Developing disease-resistant animals and disease model animals
The lab develops disease-resistant animals and animal models of neuropsychiatric disorders, and uses these animals to study the mechanisms by which diseases occur.
It creates animals that cannot be infected with herpesviruses or influenza viruses, aiming to lead to new treatments for viral infections.
The lab also works on developing methods to create new disease model animals by genome editing, and on elucidating the epigenetic regulation involved in the development and differentiation of germ cells and stem cells.
The lab's website presents it under the name "Laboratory Animal Science."
Key terms
- Disease-resistant animals
- Animals given a trait that makes them resistant to infection by viruses and other pathogens. They are studied as a new way to control infectious diseases
- Transgenic mice
- Mice that carry a gene introduced from outside and are engineered to express that gene
- Epigenetic regulation
- A mechanism that regulates how genes function without changing the DNA base sequence itself
ResearchResearch themes
Aiming to develop new treatments for viral infections, the lab develops disease-resistant animals that cannot be infected with viruses, as well as model animals of neuropsychiatric disorders. It also elucidates the mechanisms of disease onset using these animals, and conducts research related to genome editing and epigenetic regulation.
*Illustrative imageDeveloping animals that cannot be infected with viruses
Since 1990, the lab has worked on developing disease-resistant animals as a way to control infections such as those caused by herpesviruses, which establish latent infection in neurons. A 2004 paper reported that transgenic mice expressing a soluble form of a viral receptor showed resistance to infection.
*Illustrative imageAnimal models of neuropsychiatric disorders and the mechanisms of onset
Since 1995, the lab has worked on developing animal models of the pathological conditions of neuropsychiatric disorders and elucidating the pathology of their onset. A 2003 paper reported that mice expressing IE180, a transcriptional regulator of Aujeszky's disease virus (pseudorabies virus), showed neurological symptoms and impaired formation of the cerebellum.
*Illustrative imageGenome editing and the development and differentiation of germ cells
The lab works on developing methods to create new disease model animals using genome editing. Using these model animals, it aims to elucidate the epigenetic regulatory mechanisms involved in the development and differentiation of germ cells and stem cells.
*Illustrative imagePhysiological actions of neuropeptide Y
The lab works to elucidate the role that neuropeptide Y (NPY) plays in the body and the pathways through which its signals are transmitted. Its research keywords include stress, circadian rhythm, and sleep.
MembersFaculty
The members page of the Laboratory Animal Science division lists the names of the lab's members, including the faculty.
- ProfessorEiki Takahashi
- Assistant ProfessorHaruka Nishimura
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Transgenic mouse hippocamus” National Institutes of Health (NIH) / Public domain (cropped)
- Developing animals that cannot be infected with viruses: “CSIRO ScienceImage 7305 A group of transgenic sheep” Livestock Industries, CSIRO / CC BY 3.0 (cropped)
- Animal models of neuropsychiatric disorders and the mechanisms of onset: “White lab mice near” Pogrebnoj-Alexandroff / CC BY-SA 3.0 (cropped)
- Genome editing and the development and differentiation of germ cells: “Overview of TALENs” Ogletreerd / CC BY-SA 4.0 (cropped)
- Physiological actions of neuropeptide Y: “The Hypothalamus-Pituitary Complex zh” 喵叫授 / CC BY-SA 4.0 (cropped)
- Related lab (Neuroanatomy Lab): “Sagittal brain slice, UB Museum of Neuroanatomy, Buffalo, New York” Caldwbr / CC BY-SA 4.0 (cropped)
- Related lab (Developmental and Regenerative Medicine Lab): “Mouse embryo ( )” Pazit Polak from Basel, Switzerland / CC BY 2.0 (cropped)
- Related lab (Medical Chemistry Lab): “DNA Structure+Key+Labelled.pn NoBB” Zephyris / CC BY-SA 3.0 (cropped)
- Related lab (Biochemistry Lab): “A Pathway to Protocells on Titan – Animations (SVS -Cell-Membrane-Thumbnail)” NASA's Scientific Visualization Studio - NASA Goddard / Public domain (cropped)
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