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Severe Cardiopulmonary Failure Lab
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The lab studies prognosis while patients await a heart transplant and rejection after transplantation.
AboutAbout the lab
From prognosis on the transplant waiting list to rejection after transplantation
The Severe Cardiopulmonary Failure Lab studies patients with severe heart failure who need a heart transplant, as well as patients who have received one.
Among patients with severe heart failure awaiting a heart transplant, the lab studied anemia, an important comorbidity of heart failure.
After a heart transplant, patients must continue immunosuppressive therapy for life to prevent rejection, and the lab is searching for biomarkers that can serve as indicators for this therapy.
The lab is an endowed lab within the Department of Cardiovascular Surgery, Graduate School of Medicine.
Key terms
- Immunosuppressive therapy
- Treatment continued for life after a heart transplant to prevent rejection. Too little leads to rejection, and too much leads to complications such as infection.
- Biomarker
- An indicator used to decide matters such as which immunosuppressant to choose and at what dose. This lab is searching for biomarkers that can serve as indicators for optimal immunosuppressive therapy after heart transplantation.
ResearchResearch themes
Heart transplantation is now an established treatment for severe heart failure, and the number of patients continues to grow in Japan and abroad. The lab has studied the factors that determine prognosis while patients wait for a heart transplant, and it is now working to elucidate the mechanisms of rejection after transplantation.
Severe heart failure and anemia in patients awaiting transplantation
The lab studied how often anemia occurs in patients with severe heart failure awaiting a heart transplant and how it affects their clinical course. By analyzing patients registered for heart transplantation at the lab's own institution, it showed that anemia and iron deficiency are common and that anemia is an important prognostic factor during the waiting period.
Factors determining prognosis in severe heart failure
Beyond anemia, the lab analyzed other factors that determine the prognosis of patients with severe heart failure, as well as treatment strategies to improve prognosis. It has also begun building multicenter retrospective and prospective heart failure databases.
Mechanisms of rejection after heart transplantation
The lab examines biological tissue from patients after heart transplantation using mass spectrometry and multi-omics analysis, working to clarify the molecular biological changes that accompany rejection. It aims to search for and identify biomarkers that can serve as indicators for optimal immunosuppressive therapy.
MembersFaculty
- LecturerTakeo Fujino
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Ventricular Assist Device (Power Pack)” BruceBlaus / CC BY-SA 4.0 (cropped)
- Related lab (Neuroanatomy Lab): “Sagittal brain slice, UB Museum of Neuroanatomy, Buffalo, New York” Caldwbr / CC BY-SA 4.0 (cropped)
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