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Aging Pathology Repair Lab
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The lab explores the mechanisms of age-related diseases through plasmalogens.
AboutAbout the lab
Contributing to healthy aging
The Aging Pathology Repair Lab aims to clarify the mechanisms of the various diseases that arise with aging and to contribute to healthy aging.
The lab focuses on the biological roles of plasmalogens, a special class of phospholipids.
Plasmalogens are known to decrease with age, but until now their physiological functions had been largely unclear.
In addition, the lab conducts research based on the concept of "brain fatigue" and research on the relationship between the brain and the gut.
Key terms
- Plasmalogens
- Special phospholipids that are components of cell membranes. They are found in nearly all mammalian tissues and decrease with age.
- Brain fatigue
- A concept that this lab regards as important for understanding the mechanisms of aging.
NewsLab news
Joint research with the Graduate School of Agriculture proves that facultative anaerobic bacteria can also produce plasmalogens
Paper on liver plasmalogens and cholesterol metabolism published in BBA
ResearchResearch themes
To clarify the mechanisms of the various diseases associated with aging, the lab studies plasmalogens, a special type of lipid. Plasmalogens have been shown to exert diverse functions, including roles in neuroinflammation, pathologies involving memory- and aging-related genes, DNA damage, and intestinal immunity.
*Illustrative imagePlasmalogen homeostasis and anti-aging effects
The lab has discovered a mechanism that maintains plasmalogen levels by regulating their biosynthesis, and, using the cerebellum as a model, has shown how abnormalities in this mechanism impair myelin formation. It has also found substantial anti-aging effects, such as preventing glial cell activation in neuroinflammation and preventing the accumulation of amyloid-β protein.
*Illustrative imageBrain fatigue, the brain–gut axis, and roles in organs
The lab conducts research based on "brain fatigue," which it regards as an important concept in the mechanisms of aging, as well as research on the relationship between the brain and the gut (the brain–gut axis). It also investigates the roles of plasmalogens, which are distributed across various organs and tissues, from the perspective of their anti-aging effects.
MembersFaculty
The staff introduction page for the Aging Pathology Repair Lab lists a Professor.
- ProfessorMasanori Honsho
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Computed tomography of human brain - large” Department of Radiology, Uppsala University Hospital. Uploaded by Mikael Häggström. / CC0 (cropped)
- Plasmalogen homeostasis and anti-aging effects: “Phospholipid Chemicalmakeup” Veggiesaur / CC BY-SA 3.0 (cropped)
- Brain fatigue, the brain–gut axis, and roles in organs: “Integrated gut- brain- reproductive axis” Dr.Deepshikha Gupta / CC BY-SA 4.0 (cropped)
- Related lab (Neuroanatomy Lab): “Sagittal brain slice, UB Museum of Neuroanatomy, Buffalo, New York” Caldwbr / CC BY-SA 4.0 (cropped)
- Related lab (Developmental and Regenerative Medicine Lab): “Mouse embryo ( )” Pazit Polak from Basel, Switzerland / CC BY 2.0 (cropped)
- Related lab (Medical Chemistry Lab): “DNA Structure+Key+Labelled.pn NoBB” Zephyris / CC BY-SA 3.0 (cropped)
- Related lab (Biochemistry Lab): “A Pathway to Protocells on Titan – Animations (SVS -Cell-Membrane-Thumbnail)” NASA's Scientific Visualization Studio - NASA Goddard / Public domain (cropped)
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