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Musculoskeletal Sports Science Lab
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A lab tackling osteoarthritis through both knee surgery and the development of new drugs.
AboutAbout the lab
Addressing joint disease through both knee surgery and drugs
The lab studies knee joint surgery and the development of treatments for osteoarthritis.
Among knee surgeries, its research topics are UKA and interlocking OW-DTO.
It also works on developing a treatment for osteoarthritis using amlexanox, an inhibitor of the factors GRK5 and IKKε.
Drug therapy for rheumatoid arthritis is also one of its research subjects.
Key terms
- Interlocking OW-DTO
- An osteotomy that cuts the bone below the tibial tuberosity. It does not require fixation with screws in the anteroposterior direction.
- Amlexanox
- An inhibitor of GRK5 and IKKε, factors that promote NF-κB signaling. It is used in the lab's development of treatments for osteoarthritis.
ResearchResearch themes
In the field of orthopedic surgery, the lab works on knee joint surgery and the development of treatments for osteoarthritis. It also covers drug therapy for rheumatoid arthritis.
*Illustrative imageDrugs that protect cartilage and relieve pain
The lab studies a drug combining amlexanox and hyaluronic acid, aiming to protect cartilage while relieving pain in knee osteoarthritis.
*Illustrative imageOsteotomy without anteroposterior screws
The lab studies interlocking OW-DTO, an osteotomy. It is performed below the tibial tuberosity and does not require fixation with screws in the anteroposterior direction.
*Illustrative imageUKA with expanding indications
The lab studies UKA, a type of knee joint surgery, in light of its widening indications in a super-aged society.
*Illustrative imageIKKε and treatments for osteoarthritis
The lab investigates how IκB kinase ε (IKKε) is involved in the pathology of osteoarthritis, and aims to develop a treatment using its inhibitor.
MembersFaculty
- Associate ProfessorYukio Akasaki
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Knee Left X-Ray Partial Joint Front view 2018” Copeland.James.H / CC BY-SA 4.0 (cropped)
- Drugs that protect cartilage and relieve pain: “Cartilage hyaline1” Echinaceapallida / CC BY-SA 4.0 (cropped)
- Osteotomy without anteroposterior screws: “Knee plain X-ray weight bearing” Ptrump16 / CC BY-SA 4.0 (cropped)
- UKA with expanding indications: “Right Knee Post-surgery frontal implant” 作者不詳 / Public domain (cropped)
- IKKε and treatments for osteoarthritis: “Varus Knee Osteoarthritis Xray” NP2025 / CC BY-SA 4.0 (cropped)
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