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Integrative Tissue Repair Medicine Lab
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The lab uses neural stem cells as a starting point to explore regeneration of the brain and spinal cord.
AboutAbout the lab
Aiming for brain and spinal cord regeneration from the cells that give rise to neurons
The Integrative Tissue Repair Medicine Lab studies how cells of the nervous system differentiate and applies the findings to regenerative medicine.
It investigates, from an epigenetic perspective, the mechanisms by which neural stem cells become neurons and glial cells.
As ways to replace neurons lost to spinal cord injury or cerebral infarction, the lab is advancing research on neural stem cell transplantation and direct reprogramming.
It also works to elucidate the mechanisms underlying the onset of autism spectrum disorder.
Key terms
- Neural stem cell
- Neural stem cell: a cell that gives rise to neurons and glial cells. It is used in research on differentiation mechanisms and on regeneration through transplantation.
- Epigenetics
- Epigenetics: mechanisms that regulate gene activity through DNA methylation, histone modification, and the like, without changing the DNA sequence.
- Direct reprogramming
- Direct reprogramming: a technique that introduces genes for specific transcription factors to convert non-neuronal cells directly into neurons.
ResearchResearch themes
The lab studies the mechanisms that control the differentiation of nervous system cells and their application to regenerative medicine. It investigates ways to replace neurons lost in the injured spinal cord and brain, as well as the mechanisms underlying the onset of autism spectrum disorder.
*Illustrative imageNeural Stem Cell Transplantation for Spinal Cord Injury
In research recognized with a Commendation by the Minister of Education, Culture, Sports, Science and Technology, the lab found a method to regenerate neurons with high efficiency from neural stem cells transplanted into the injured spinal cord, by administering an antiepileptic drug. Transplantation of human iPS cell-derived neural stem cells substantially improved hindlimb function in mice with spinal cord injury.
*Illustrative imageDirect Reprogramming and Cerebral Infarction
The same commendation also covered research in which direct reprogramming, which artificially converts immune cells in the brain directly into neurons, restored neurological function in a mouse model of cerebral infarction.
*Illustrative imageMechanisms That Determine Neural Stem Cell Differentiation
The lab investigates, from an epigenetic perspective such as DNA methylation, the mechanisms by which neural stem cells differentiate into neurons, astrocytes, and oligodendrocytes.
*Illustrative imageMechanisms of Autism Spectrum Disorder Onset
The lab works to elucidate the mechanisms underlying the onset of autism spectrum disorder.
MembersFaculty
- ProfessorKinichi Nakashima
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Nervous Tissue Spinal Cord Motor Neuron ( )” Berkshire Community College Bioscience Image Library / CC0 (cropped)
- Neural Stem Cell Transplantation for Spinal Cord Injury: “Neural Stem Cells” Welcome Collection / CC BY-SA 4.0 (cropped)
- Direct Reprogramming and Cerebral Infarction: “Histopathology of ischemic stroke of the thalamus at approximately 24 hours” Mikael Häggström, M.D. Author info - Reusing images- Conflicts of interest: None Mikael Häggström, M.D.Consent note: Consent from the patient or patient's relatives is regarded as redundant, because of absence of identifiable features (List of HIPAA identifiers) in the media and case information (See also HIPAA case reports guidance). / CC0 (cropped)
- Mechanisms That Determine Neural Stem Cell Differentiation: “Differentiation Neural Progenitors” National Institutes of Health (NIH) / Public domain (cropped)
- Mechanisms of Autism Spectrum Disorder Onset: “Autism Theory of Mind” MissLunaRose12 / CC BY-SA 4.0 (cropped)
- Related lab (Neuroanatomy Lab): “Sagittal brain slice, UB Museum of Neuroanatomy, Buffalo, New York” Caldwbr / CC BY-SA 4.0 (cropped)
- Related lab (Developmental and Regenerative Medicine Lab): “Mouse embryo ( )” Pazit Polak from Basel, Switzerland / CC BY 2.0 (cropped)
- Related lab (Medical Chemistry Lab): “DNA Structure+Key+Labelled.pn NoBB” Zephyris / CC BY-SA 3.0 (cropped)
- Related lab (Biochemistry Lab): “A Pathway to Protocells on Titan – Animations (SVS -Cell-Membrane-Thumbnail)” NASA's Scientific Visualization Studio - NASA Goddard / Public domain (cropped)
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