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Cancer Stem Cell Medicine Lab
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The lab studies the stem cells that give rise to blood and the bone marrow environment that supports them.
AboutAbout the lab
Exploring stem cells and the environment that supports them
The Cancer Stem Cell Medicine Lab studies hematopoietic stem cells, which give rise to blood, and the bone marrow environment (niche) that supports them.
It focuses on mesenchymal stem cells that support hematopoietic stem cells in the bone marrow, and on shelterin, a group of proteins involved in stem cell aging.
The lab also investigates how hematologic malignancies such as leukemia and multiple myeloma interact with the bone marrow environment.
Key terms
- Hematopoietic stem cell
- Hematopoietic stem cell: a stem cell in the bone marrow that gives rise to the various types of blood cells.
- Niche
- Niche: a special environment next to stem cells that works to maintain their properties.
- Mesenchymal stem cell
- Mesenchymal stem cell: a stem cell that can differentiate into cells such as bone cells. In the bone marrow, it is one of the cell types that support hematopoietic stem cells.
- Shelterin
- Shelterin: a group of proteins that protect the ends of chromosomes (telomeres). Pot1a is one of its members.
ResearchResearch themes
The lab studies the bone marrow environment that supports hematopoietic stem cells, as well as stem cell aging. It also investigates how hematologic malignancies such as leukemia interact with the bone marrow environment.
*Illustrative imageMesenchymal Stem Cells Supporting Hematopoiesis
The lab studies the bone marrow niche that supports hematopoietic stem cells, focusing on mesenchymal stem cells. In a published paper, it reported that integrin α8-expressing mesenchymal stem cells located on the inner side of bone maintain hematopoietic stem cell function.
*Illustrative imageStem Cell Aging and Shelterin
Focusing on Pot1a, a member of the shelterin complex, the lab investigates its relationship to aging of tissue stem cells. In a published paper, it showed that when mesenchymal stem cells lack Pot1a, they can no longer support B cell production.
*Illustrative imageAsymmetric Division of Hematopoietic Stem Cells
The lab studies asymmetric division, which occurs when hematopoietic stem cells divide, with the aim of clarifying the underlying mechanism.
*Illustrative imageHematologic Malignancies and the Bone Marrow Environment
The lab studies how hematologic malignancies such as leukemia and multiple myeloma interact with the bone marrow microenvironment. In a published paper, it reported that acute myeloid leukemia stem cells remodel the bone marrow niche to create an environment that supports themselves.
MembersFaculty
- ProfessorFumio Arai
- Assistant ProfessorHisayuki Yao
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Human bone marrow derived MSCs” Chinmaya Mahapatra / CC BY-SA 3.0 (cropped)
- Mesenchymal Stem Cells Supporting Hematopoiesis: “Whartons-jelly-mesenchymal-stem-cells” [<a href="https://www.amaskincare.com/about/alice-pien-md-medical-director/">Alice Pien, MD</a>] / CC BY-SA 4.0 (cropped)
- Stem Cell Aging and Shelterin: “Telomeres transparent” AJC1 / CC BY-SA 4.0 (cropped)
- Asymmetric Division of Hematopoietic Stem Cells: “Asymmetric cell division in Drosophila neuroblasts - 486169.fig.004” Nidhi Saini and Heinrich Reichert (2012) / CC BY 3.0 (cropped)
- Hematologic Malignancies and the Bone Marrow Environment: “Bone Marrow Transplant” Mugwump12 / CC BY-SA 3.0 (cropped)
- Related lab (Neuroanatomy Lab): “Sagittal brain slice, UB Museum of Neuroanatomy, Buffalo, New York” Caldwbr / CC BY-SA 4.0 (cropped)
- Related lab (Developmental and Regenerative Medicine Lab): “Mouse embryo ( )” Pazit Polak from Basel, Switzerland / CC BY 2.0 (cropped)
- Related lab (Medical Chemistry Lab): “DNA Structure+Key+Labelled.pn NoBB” Zephyris / CC BY-SA 3.0 (cropped)
- Related lab (Biochemistry Lab): “A Pathway to Protocells on Titan – Animations (SVS -Cell-Membrane-Thumbnail)” NASA's Scientific Visualization Studio - NASA Goddard / Public domain (cropped)
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