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Stem Cell Regeneration and Repair Medicine Lab
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The lab explores regeneration and leukemia through hematopoietic stem cells and the niche environment that supports them.
AboutAbout the lab
Understanding stem cells through the lens of the bone marrow niche
The lab studies how the self-renewal and differentiation of hematopoietic stem cells, the source of blood cells, are controlled.
Stem cell function is thought to be regulated through the relationship with the surrounding microenvironment known as the niche, and the lab investigates the cells and molecules that form the niche in the bone marrow.
The lab also works as a cancer stem cell medicine field, conducting research on treating blood cancers by targeting leukemia stem cells and the niche that supports them.
Key terms
- Hematopoietic stem cell
- The cell that gives rise to all blood cells. It can produce cells identical to itself and can also differentiate
- Niche
- The microenvironment surrounding stem cells. Stem cell function is regulated through the relationship with this environment
- Leukemia stem cell
- The cell from which leukemia originates. It is resistant to chemotherapy and is considered one cause of relapse
NewsLab news
A study on the bone marrow microenvironment in acute myeloid leukemia was published in Leukemia
Undergraduate students received the Best Poster Award and the Best Presentation Award
ResearchResearch themes
The lab aims to understand hematopoietic stem cells and their niche, as well as leukemia stem cells and the leukemia niche, by connecting the levels of the whole organism, tissues, and molecules. It works to clarify how hematopoietic stem cells, the source of blood cells, self-renew and differentiate, and to conduct research on treating blood cancers by targeting cancer stem cells.
Investigating the Function of Niche Molecules
The lab studies how signals from the niche play an important role in controlling hematopoietic stem cell divisions, such as divisions that produce two stem cells and divisions that produce one stem cell and one progenitor cell. In collaboration with mathematicians, the lab established a method that analyzes gene expression in the two daughter cells of a single stem cell one cell at a time to distinguish the mode of division.
*Illustrative imageMaintaining Hematopoietic Stem Cells Outside the Body
Manipulating genes in vitro while preserving the function of hematopoietic stem cells is a difficult challenge. In an international collaboration with bioengineering researchers, the lab is working to build artificial niches, and has confirmed through cell division analysis that hematopoietic stem cells increase in number when cultured on an artificial niche made of hydrogel.
*Illustrative imageIdentifying the Hematopoietic Stem Cell Niche
Using three-dimensional bone marrow imaging with reporter mice, the lab examines the positional relationship between hematopoietic stem cells and surrounding cells, and searches for the niches specific to activated stem cells and to quiescent stem cells. By isolating the cells that form these niches, the lab hopes to clarify how stem cells switch between activation and quiescence.
*Illustrative imageAnalyzing the Leukemia Stem Cell Niche
Using mouse models of leukemia, the lab investigates the bone marrow niche where leukemia stem cells, one cause of leukemia relapse, reside. It has shown that cells of the endosteal niche keep leukemia stem cells in a quiescent state that resists treatment.
MembersFaculty
The members of the Stem Cell Regeneration and Repair Medicine Lab are faculty, master's and undergraduate students, collaborating researchers, academic researchers, and secretaries.As of 2026
- ProfessorFumio Arai
- LecturerKentaro Hosokawa
- Assistant ProfessorNaoyuki Yao
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Nucleated red blood cell with Cabot rings and basophilic granules” Makysm / CC0 (cropped)
- Maintaining Hematopoietic Stem Cells Outside the Body: “Epithelioid cells and macrophages in cell culture” ArkhipovSergey / CC BY-SA 4.0 (cropped)
- Identifying the Hematopoietic Stem Cell Niche: “Bone marrow cellularity in QuPath” Mikael Häggström, M.D. Author info - Reusing images- Conflicts of interest: None Mikael Häggström, M.D.Consent note: Consent from the patient or patient's relatives is regarded as redundant, because of absence of identifiable features (List of HIPAA identifiers) in the media and case information (See also HIPAA case reports guidance). / Public domain (cropped)
- Analyzing the Leukemia Stem Cell Niche: “Leukemia Diagram Detailing Stem Cell to Blood Cell Maturation Process” Ibdipcan2015 / CC BY-SA 4.0 (cropped)
- Related lab (Neuroanatomy Lab): “Sagittal brain slice, UB Museum of Neuroanatomy, Buffalo, New York” Caldwbr / CC BY-SA 4.0 (cropped)
- Related lab (Developmental and Regenerative Medicine Lab): “Mouse embryo ( )” Pazit Polak from Basel, Switzerland / CC BY 2.0 (cropped)
- Related lab (Medical Chemistry Lab): “DNA Structure+Key+Labelled.pn NoBB” Zephyris / CC BY-SA 3.0 (cropped)
- Related lab (Biochemistry Lab): “A Pathway to Protocells on Titan – Animations (SVS -Cell-Membrane-Thumbnail)” NASA's Scientific Visualization Studio - NASA Goddard / Public domain (cropped)
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