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Pathophysiology and Restorative Internal Medicine Lab
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An internal medicine lab whose clinical groups in hematology, oncology, cardiovascular medicine, and other fields confront disease.
AboutAbout the lab
Each clinical group tackles the diagnosis and treatment of disease.
The Pathophysiology and Restorative Internal Medicine Lab (First Department of Internal Medicine) is made up of clinical groups for hematology, oncology, cardiovascular medicine, collagen disease, infectious disease, and the liver.
Each group works on the diagnosis and treatment of diseases in its own field.
In his researcher profile, Prof. Kikushige lists hematopoietic stem cells and leukemic stem cells as his research themes.
Key terms
- Chemotherapy
- A method of treating disease using drugs such as anticancer drugs
- Molecular targeted drug
- A drug designed to act by aiming at a specific molecule involved in a disease
- Connective tissue disease (collagen disease)
- A collective name for diseases classed as autoimmune diseases, such as systemic lupus erythematosus and rheumatoid arthritis
NewsLab news
Prof. Kikushige is scheduled to receive a special award for industry-academia-government collaboration at Kyushu University OIW 2026 (10/28)
A paper from the hematology group was published in International Journal of Hematology
A paper co-authored with Nagoya University was published in Haematologica
ResearchResearch themes
The First Department of Internal Medicine is an internal medicine lab that works on the diagnosis and treatment of disease in hematology, oncology, cardiovascular medicine, collagen disease, infectious disease, and the liver. The oncology group provides chemotherapy, and the collagen disease group provides drug therapy using immunosuppressants and molecular targeted drugs.
*Illustrative imageChemotherapy for Gastrointestinal and Rare Cancers
The lab provides chemotherapy using anticancer drugs and molecular targeted drugs, and develops treatments, for gastrointestinal cancers such as esophageal, gastric, and colorectal cancer, rare cancers such as sarcoma, and other solid tumors.
*Illustrative imageDiagnosis and Treatment of Heart and Vascular Diseases
The lab diagnoses and treats heart diseases such as coronary artery disease, valvular heart disease, and cardiomyopathy, and vascular diseases such as arterial diseases, venous diseases, and vasculitis. It also handles cardiovascular diseases related to systemic illness, including cardio-oncology.
*Illustrative imageDrug Therapy for Autoimmune Diseases
For autoimmune diseases such as systemic lupus erythematosus and rheumatoid arthritis, the lab provides drug therapy using immunosuppressants and molecular targeted drugs.
*Illustrative imageCare for Infections That Are Difficult to Diagnose and Treat
For a variety of infections that are difficult to diagnose or treat, the lab selects and administers antimicrobial drugs appropriately. It also works on infection prevention and control.
MembersFaculty
The members of the Pathophysiology and Restorative Internal Medicine Lab (First Department of Internal Medicine) consist of faculty, hospital staff physicians, and graduate students.As of 2026
- ProfessorYoshikane Kikushige
- Assistant ProfessorMamoru Ito
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “SEM blood cells” Bruce Wetzel (photographer). Harry Schaefer (photographer) / Public domain (cropped)
- Chemotherapy for Gastrointestinal and Rare Cancers: “Chemotherapy vials (4)” Bill Branson (Photographer) / Public domain (cropped)
- Diagnosis and Treatment of Heart and Vascular Diseases: “2D ECHOCARDIOGRAM MACHINE WITH A TABLE AND A STETHOSCOPE” Dr D. Malleswara Rao / CC BY-SA 4.0 (cropped)
- Drug Therapy for Autoimmune Diseases: “Warm autoimmune hemolytic anemia” E. Uthman, MD / CC BY-SA 2.0 (cropped)
- Care for Infections That Are Difficult to Diagnose and Treat: “Influenza virus research” Photo Credit: James Gathany Content Providers(s): CDC / Public domain (cropped)
- Related lab (Morphology and Functional Pathology Lab): “Smooth muscle (histology slide)” Juan Carlos Fonseca Mata / CC BY-SA 4.0 (cropped)
- Related lab (Pathology and Pathophysiology Lab): “Artery” Lord of Konrad / CC0 (cropped)
- Related lab (Urology Lab): “Ultrasound of left kidney lower pole with stone” Cerevisae / CC BY-SA 4.0 (cropped)
- Related lab (Collaborative Oncology Lab): “Killer T cells surround a cancer cell” The National Institutes of Health / Public domain (cropped)
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