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Structural Pathology Lab
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This lab investigates diseases of the liver, biliary tract, and pancreas from the standpoint of pathology.
AboutAbout the lab
Carrying on morphological diagnosis toward the next generation of pathology
From the standpoint of pathology, the lab aims to contribute to elucidating disease mechanisms and function, establishing new diagnostic methods, and developing new treatments, focusing mainly on diseases of the liver, biliary tract, and pancreas.
Using molecular pathology, the lab studies the process of carcinogenesis and the immune microenvironment around tumors in a variety of tumors, including digestive diseases in general and tumors of the breast and respiratory organs.
The lab's philosophy is to carry on morphological diagnosis, "examining morphology until a hole is worn through," a tradition unique to Kyushu University, while developing pathology research and diagnostics full of promise that lead to the next generation.
Through broad pathological research, including morphological pathology, molecular pathology, and experimental pathology, graduate students develop the ability to find and solve problems on their own.
Key terms
- Morphological diagnosis
- A diagnostic method in which the shapes of tissues and cells are carefully observed under a microscope or other instruments to determine a disease.
- Immune microenvironment
- The environment around a tumor formed by immune-related cells, molecules, and other components.
- Intrahepatic cholangiocarcinoma
- Cancer that arises in the bile ducts inside the liver. It is classified into two types.
- MASLD/MASH
- Fatty liver associated with metabolic abnormalities (MASLD), and the form of it accompanied by inflammation (MASH).
NewsLab news
View More ↗ResearchResearch themes
From the standpoint of pathology, the lab aims to contribute to elucidating disease mechanisms and function, establishing new diagnostic methods, and developing new treatments, focusing mainly on diseases of the liver, biliary tract, and pancreas. Using molecular pathology, the lab analyzes carcinogenesis and the immune microenvironment during tumor formation in a variety of tumors, including digestive diseases in general and tumors of the breast and respiratory organs.
*Illustrative imageHow intrahepatic cholangiocarcinoma grows and spreads
Intrahepatic cholangiocarcinoma is divided into the Large duct type and the Small duct type, and the characteristics of each have become clearer. In addition to differences in cell shape, the lab analyzes differences at the molecular genetic level, differences in the immune microenvironment, and differences in responsiveness to treatment.
*Illustrative imageElucidating the pathology of steatohepatitis
The lab performs central pathological diagnosis of MASLD/MASH, including in domestic multicenter collaborative studies and with affiliated institutions overseas. With the aim of establishing new diagnostic methods and biomarkers and elucidating the disease mechanisms, the lab analyzes large numbers of human specimens and conducts studies in animal models.
MembersFaculty
The lab's members consist of faculty, technical staff, graduate students, and collaborative researchers.As of 2026
- ProfessorShinichi Aishima
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Histology of liver tissue from a gallbladder resection” Mikael Häggström, M.D. Author info - Reusing images- Conflicts of interest: None Mikael Häggström, M.D.Consent note: Consent from the patient or patient's relatives is regarded as redundant, because of absence of identifiable features (List of HIPAA identifiers) in the media and case information (See also HIPAA case reports guidance). / CC0 (cropped)
- How intrahepatic cholangiocarcinoma grows and spreads: “Immunohistochemistry for CK19 in metastatic cholangiocarcinoma to the liver” Mikael Häggström, M.D. Author info - Reusing images- Conflicts of interest: None Mikael Häggström, M.D.Consent note: Consent from the patient or patient's relatives is regarded as redundant, because of absence of identifiable features (List of HIPAA identifiers) in the media and case information (See also HIPAA case reports guidance). / CC0 (cropped)
- Elucidating the pathology of steatohepatitis: “Liver steatosis fatty change” Laboratory of Experimental Pathology, Division of Intramural Research, NIEHS (NIH) / Public domain (cropped)
- Related lab (Clinical Laboratory Medicine Lab): “Europa Clipper's Mass Spectrometer” NASA/JPL-Caltech / Public domain (cropped)
- Related lab (Urology Lab): “Ultrasound of left kidney lower pole with stone” Cerevisae / CC BY-SA 4.0 (cropped)
- Related lab (Medical Engineering Lab): “Tube à Rayon X dans un hôpital au Bénin 05” Adoscam / CC BY-SA 4.0 (cropped)
- Related lab (Anesthesiology and Resuscitation Lab): “Physician anesthesiologist” Lt.Cmdr. Jesse Ehrenfeld / Public domain (cropped)
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