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Clinical Laboratory Medicine Lab
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The lab analyzes clinical specimens collected at the hospital using mass spectrometry and other methods, aiming for clinical application.
AboutAbout the lab
Aiming for clinical application of integrated omics technologies
The Clinical Laboratory Medicine Lab studies human specimens collected at the Clinical Laboratory Department of Kyushu University Hospital, analyzing them with mass spectrometry and spatial omics.
The lab is a graduate school department set up alongside the Clinical Laboratory Department of Kyushu University Hospital.
The lab aims to comprehensively capture the molecular characteristics of each individual's body and to contribute to the discovery of biomarkers needed for disease prevention and early diagnosis.
Multiple themes are underway in parallel, including the mechanisms of thrombus formation, obesity, drug-resistant bacteria, and genetic analysis of thrombosis.
Key terms
- Omics
- Analysis that comprehensively examines molecules in the body. Targets include metabolites, lipids, and proteins.
- Spatial omics
- A method for analyzing gene expression patterns by location, for individual cells and fine structures within tissue.
- Biomarker
- An indicator, such as a molecule in the body, that provides clues about the presence of a disease or how well a treatment is working.
- VWF
- An adhesion molecule in the blood. It binds to GPIbα, a membrane protein on platelets, and triggers platelet aggregation.
NewsLab news
A paper by a PhD student has been accepted for publication in Research and Practice in Thrombosis and Haemostasis
A collaborative study with Nagoya University has been accepted for publication in Precision Chemistry
A paper by a researcher in the Clinical Laboratory Department has been accepted for publication in Diagnostics
A master's student received the Young Investigator Award at the Japan Society of Clinical Chemistry
A collaborative study with the Department of Pediatrics at Kyushu University has been accepted for publication in Brain and Development
ResearchResearch themes
The lab analyzes human specimens collected at the Clinical Laboratory Department in multiple dimensions using mass spectrometry and spatial omics, aiming to comprehensively capture the molecular profile of each individual's body. As the lab closest to the clinical setting, it aims to provide a collaborative research platform open to all clinical departments and to return research results quickly to clinical practice.
*Illustrative imageHow blood clots form, and antiplatelet drugs
Arterial thrombosis occurs when VWF in the blood binds to GPIbα, a membrane protein on platelets, causing the platelets to aggregate. The lab creates mice humanized for this interaction and aims to develop antiplatelet drugs that suppress pathological thrombus formation while preserving normal hemostasis.
*Illustrative imageSearching for biomarkers with clinical omics
The lab conducts data-driven research that combines metabolome, lipidome, and proteome analyses using multiple mass spectrometers with spatial transcriptome analysis. In collaboration with the hospital's clinical laboratory department, it aims to search for disease-related biomarkers and develop clinical laboratory tests.
*Illustrative imageThe mechanism behind obesity-resistant mice
The lab found that mice engineered to produce large amounts of human TFAM (mitochondrial transcription factor A) do not easily gain weight even on a high-fat diet, with brown adipose tissue activity maintained and metabolism elevated. The lab is working to clarify this mechanism and develop new treatments for obesity.
*Illustrative imageGenome evolution of drug-resistant bacteria
When drug-resistant bacteria are exposed to antibiotics inside a patient's body, their DNA sequences can change, giving rise to bacteria with even stronger resistance. The lab uses genome analysis to clarify how these changes occur, aiming to create new countermeasures against resistance that suppress this evolution.
MembersFaculty
The members of the Clinical Laboratory Medicine Lab consist of professors, associate professors, assistant professors, lecturers, hospital medical staff, PhD and master's students, technical staff, administrative assistants, researchers from the Clinical Laboratory Department, collaborative researchers, and part-time lecturers.As of 2026
- ProfessorYuya Kunizaki
- Associate ProfessorSachiko Kanaji
- Assistant Professor (Hospital)Ruriko Nishida
- Assistant Professor (Endowed Chair: Collaborative General Internal Medicine)Ikumi Yamanaka
- Lecturer (Department of Health Sciences, Kyushu University)Masamune Aihara
- Assistant Professor (School of Health Sciences, Kyushu University)Saori Ueda
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Europa Clipper's Mass Spectrometer” NASA/JPL-Caltech / Public domain (cropped)
- How blood clots form, and antiplatelet drugs: “WBC (neutrophil) at centre, numerous erythrocytes and platelets (dot like bodies) in Wright's stained peripheral blood smear (PBS) microscopy” Ajay Kumar Chaurasiya / CC BY-SA 4.0 (cropped)
- Searching for biomarkers with clinical omics: “Biological Mass Spectrometry ( )” Oak Ridge National Laboratory / CC BY 2.0 (cropped)
- The mechanism behind obesity-resistant mice: “Animals - Obese mouse -- Smart-Servier” Laboratoires Servier / CC BY-SA 3.0 (cropped)
- Genome evolution of drug-resistant bacteria: “Methicillin-Resistant Staphylococcus Aureus (MRSA) Bacteria colorized scanning electron micrograph - 22” NIAID / CC BY 2.0 (cropped)
- Related lab (Pharmacology Lab): “Фармацевтско-лабараториски техничар” Blagojcedisoski / CC BY-SA 3.0 (cropped)
- Related lab (Structural Pathology Lab): “Histology of liver tissue from a gallbladder resection” Mikael Häggström, M.D. Author info - Reusing images- Conflicts of interest: None Mikael Häggström, M.D.Consent note: Consent from the patient or patient's relatives is regarded as redundant, because of absence of identifiable features (List of HIPAA identifiers) in the media and case information (See also HIPAA case reports guidance). / CC0 (cropped)
- Related lab (Neurology Lab): “Functional and anatomical connectivity in the brain using MRI data 05” MGromov / CC BY-SA 4.0 (cropped)
- Related lab (Urology Lab): “Ultrasound of left kidney lower pole with stone” Cerevisae / CC BY-SA 4.0 (cropped)
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