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Laboratory Animal Science Lab
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This lab explores how the brain works through animal models of neurological disease and gut bacteria.
AboutAbout the lab
Exploring neurological disease and brain function with animal models
The lab's main research topics are the development of animal models of neurological disease and the analysis of how gut bacteria affect brain function.
The lab's Professor researches how environmental factors affect neurological disease.
The Assistant Professor's research theme is the role of neuropeptide Y in physiological function, with stress, circadian rhythm, and sleep as keywords.
In the third-year lab assignment, students practice molecular analysis using samples collected in animal experiments.
Key terms
- Gut microbiota
- The community of many kinds of bacteria living in the intestine. Its relationship with brain function is being studied.
- Neuropeptide Y
- A type of peptide that acts in the nervous system. Abbreviated NPY. Its relationship with stress and sleep is being studied.
- Circadian rhythm
- A rhythm within the body in which states such as sleep and activity change periodically in line with light and dark.
ResearchResearch themes
The lab's main research topics are the development of animal models of neurological disease and the analysis of how gut bacteria affect brain function. The lab also studies the actions of neuropeptide Y in animals such as chicks and hamsters.
*Illustrative imageHow environmental factors affect neurological disease
The lab is developing animal models of neurological disease and analyzing how gut bacteria affect brain function. Research keywords include animal models, gut microbiota, and behavioral analysis.
*Illustrative imageExploring the actions of neuropeptide Y
The lab studies the roles of neuropeptide Y in the body and how its signals are transmitted. Findings include that high temperature increases expression of the Y4 receptor in the spleen of chicks (an international co-authored study), and that the Y1 receptor may be involved in the antiviral response to SARS-CoV-2 infection in Syrian hamsters.
*Illustrative imageCircadian rhythm experiments using birds
The lab has established a method for conducting circadian rhythm experiments in the Bengalese finch, a small bird. By dressing the birds in a custom-made garment containing a nanotag, activity can be recorded without affecting flight, body temperature, or body weight. The experiments showed that the birds' activity rhythm depends strongly on lighting conditions.
MembersFaculty
The lab's members consist of a Professor, an Assistant Professor, and other members.
- ProfessorEiki Takahashi
- Assistant ProfessorHaruka Nishimura
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Laboratory ICR Mouse post-Stereotactic surgery” Minyoung Choi from Cupertino, CA, USA / CC BY-SA 2.0 (cropped)
- How environmental factors affect neurological disease: “Effect of coffee compounds on the brain–gut axis” Iriondo-DeHond, A.; Uranga, J.A.; del Castillo, M.D.; Abalo, R. / CC BY 4.0 (cropped)
- Exploring the actions of neuropeptide Y: “MMDB ID 74246 PDB ID 1RON Human Neuropeptide Y 01” Nevit Dilmen (talk) / CC BY-SA 3.0 (cropped)
- Circadian rhythm experiments using birds: “Gallus gallus domesticus - Vogelpark Steinen 03” H. Zell / CC BY-SA 3.0 (cropped)
- Related lab (Bacteriology Lab): “Bacteria in the gut” NIH Image Gallery / CC BY 2.0 (cropped)
- Related lab (Collaborative Oncology Lab): “Killer T cells surround a cancer cell” The National Institutes of Health / Public domain (cropped)
- Related lab (Pediatric Surgery Lab): “Pediatric emergency room at Iashvili Children's Hospital in Tbilisi, Georgia” AIHA, USAID / Public domain (cropped)
- Related lab (Systematic Anatomy Lab): “Giant Puffer fish skin pattern” Chiswick Chap / CC BY-SA 3.0 (cropped)
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