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Complex Molecular Chemistry Lab
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The lab uses organic chemistry as its foundation for drug discovery and chemical biology research.
AboutAbout the lab
Taking on life science research with the power of organic chemistry
The Complex Molecular Chemistry Lab (Suzuki Lab) works on drug discovery, using organic chemistry as its foundation to create organic compounds that produce the intended pharmacological effect.
The lab pursues chemical biology, which creates bioactive substances with new functions and uses them to elucidate biological phenomena, as well as medicinal chemistry research aimed at applications as pharmaceuticals.
Drawing on broad knowledge of synthetic organic chemistry, reaction chemistry, computational chemistry, and biochemistry, the lab synthesizes new bioactive substances and elucidates their mechanisms of action.
The lab is equipped with both instruments for evaluating biological activity and facilities for organic synthesis.
Key terms
- Epigenetics
- A mechanism that controls gene expression without depending on the DNA base sequence
- Click chemistry
- A method of making new functional molecules using reactions that join multiple compounds efficiently and simply
- Target-guided synthesis
- A method that uses the catalytic reaction or pocket of the target enzyme to have the inhibitor made inside the enzyme
NewsLab news
A master's student received the Student Excellent Presentation Award (poster presentation) at the 146th Annual Meeting of the Pharmaceutical Society of Japan
An undergraduate student received the Chemistry Division Excellence Award at the graduation research presentation of the Department of Biological Sciences, School of Science
Assistant Professor Takada received a poster award at Pacifichem 2025
A doctoral student received the Best Discussion Award at the Seiyuken Symposium 2026
A master's student received the Student Excellent Presentation Award (oral presentation) at the General Meeting and Conference of the Kansai Branch of the Pharmaceutical Society of Japan
ResearchResearch themes
Based on organic chemistry, the lab works on drug discovery, creating organic compounds that produce the intended pharmacological effect. Drawing on knowledge of synthetic organic chemistry, reaction chemistry, computational chemistry, structural biology, biochemistry, molecular biology, and genetics, it synthesizes new bioactive substances and elucidates their mechanisms of action.
Drug Discovery for Compounds That Control Epigenetics
Abnormalities in epigenetics have been reported to be involved in diseases such as cancer. Aiming at next-generation epigenetic drugs, the lab conducts research on creating isozyme-selective inhibitors of histone deacetylase (HDAC) and inhibitors of histone demethylases.
*Illustrative imageDrug Discovery Using Click Chemistry
The lab builds libraries of small-molecule compounds by click chemistry to search for new bioactive substances. By preparing a library of HDAC inhibitors with copper-catalyzed azide-alkyne cycloaddition, it has succeeded in creating specific inhibitors of HDAC3 and HDAC8.
*Illustrative imageMaking Inhibitors by Target-Guided Synthesis
The lab uses target-guided synthesis, in which the catalytic reaction of the target enzyme or the pocket unique to that enzyme is used to have the enzyme itself synthesize an inhibitor on the spot. It has succeeded in creating inhibitors of SIRT1, HDAC8, and LSD1.
*Illustrative imageAnalysis of Noncovalent Interactions
Hydrogen bonds and hydrophobic interactions play important roles in the reversible binding between a ligand and its target protein. The lab analyzes these interactions using computational science and analytical chemistry methods based on small-molecule models.
MembersFaculty
The members of the Suzuki Lab consist of faculty, visiting professors, JSPS research fellows, postdoctoral researchers, doctoral, master's, and undergraduate students, and secretaries.As of 2026
- Assistant ProfessorYasunobu Yamashita
- Assistant ProfessorYuri Takada
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Epigenetics modifications” Jean141 / CC BY-SA 4.0 (cropped)
- Drug Discovery Using Click Chemistry: “Ribavirin 3D” Jovan.gec / CC BY-SA 4.0 (cropped)
- Making Inhibitors by Target-Guided Synthesis: “PDB 1GXF” Boghog / CC BY-SA 4.0 (cropped)
- Analysis of Noncovalent Interactions: “Liquid water hydrogen bond” Thomas Splettstoesser (www.scistyle.com) / CC BY-SA 3.0 (cropped)
- Related lab (Advanced Functional Molecules Lab): “Chlorantraniliprole Ball-N-Stick Avogadro 20200908” Mplanine / CC BY-SA 4.0 (cropped)
- Related lab (Biomolecular Regulation Science Lab): “Antibiotic sensitivity and resistance” Dr Graham Beards / CC BY-SA 4.0 (cropped)
- Related lab (Molecular System Creation Chemistry Lab): “Reflexión total” Arturo Francisco Barbero / CC BY-SA 4.0 (cropped)
- Related lab (Nagai Lab): “Abnormal transfected HEK 293 cell” Borys Olifirov / CC BY 4.0 (cropped)
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