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Functional Immunogenomics Lab
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The lab uncovers how the selective use of genetic information determines the fate and function of immune cells.
AboutAbout the lab
Decoding immune cell fate through gene regulation.
The Functional Immunogenomics Lab studies how the programs that regulate genes control the fate and function of immune cells.
All cells in the human body carry the same genetic information, but by using it in a precisely selective way, they give rise to a variety of cells with different functions.
By combining screening that manipulates gene function with single-cell analysis, and applying them to patient-derived samples, the lab also aims to identify abnormalities in gene regulation in the immune system that lead to disease.
The ultimate goal is to translate the findings into next-generation immune cell therapies for treating disease.
The lab belongs to the Immunology Group of the Immunology Frontier Research Center.
Key terms
- Single-cell analysis
- Single-cell analysis: analysis that simultaneously measures diverse molecular information, such as RNA, proteins, and chromatin, in each individual cell.
- Screening
- Screening: a method that manipulates gene function and examines the changes that result.
- Epigenetic
- Epigenetic: relating to mechanisms that switch how genes are used without changing the DNA sequence itself.
ResearchResearch themes
All cells in the human body carry the same genetic information, and by using it selectively they give rise to cells with different functions. This lab aims to clarify how the programs that regulate genes control the fate and function of immune cells, and to translate that knowledge into next-generation immune cell therapies.
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MembersFaculty
- Associate ProfessorKelvin Chen
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images.
- Top image: “Chromatin (NIH BioArt )” Courtesy of NIAID Ryan Kissinger / Public domain (cropped)
- Gene regulation that determines immune cell identity: “Single Cell RNA Seq (NIH BioArt 767)” Courtesy of NIAID Ryan Kissinger / Public domain (cropped)
- Related lab (Immunochemistry Lab): “Westgate Microscopy t-lymphocytes” Cannons Law Firm, Glasgow, UK / CC BY 4.0 (cropped)
- Related lab (Human Immunology (Single Cell Genomics) Lab): “Natural Killer Cell (NIH BioArt )” Courtesy of NIAID Ryan Kissinger / Public domain (cropped)
- Related lab (Experimental Immunology Lab): “HIV H9 T-cell II” National Institutes of Health (NIH) / Public domain (cropped)
- Related lab (Molecular Neuroscience Lab): “Nervous Tissue Spinal Cord Motor Neuron ( )” Berkshire Community College Bioscience Image Library / CC0 (cropped)
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