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Human Immunology (Single Cell Genomics) Lab
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The lab uses single-cell analysis to decode human immunity.
AboutAbout the lab
Studying human immunity one cell at a time.
Okuzaki Lab studies human immunology at the Immunology Frontier Research Center, with a focus on single-cell analysis.
During the COVID-19 pandemic, the lab took part as a member of "Team Osaka University," performing single-cell analysis of cells in the blood (peripheral blood mononuclear cells).
The lab also uses single-cell analysis to examine immune responses after vaccination and the host immune responses to viruses and bacteria.
It also puts effort into applying the technology to connect basic research and clinical practice.
Key terms
- Single-cell analysis
- An analytical method that examines cells one by one to read differences between individual cells.
- Peripheral blood mononuclear cells (PBMC)
- A group of immune-related cells in the blood, such as lymphocytes and monocytes.
- NK cells
- A type of immune cell. They have cytotoxic activity, damaging and eliminating target cells.
NewsLab news
A technical assistant won an Excellent Presentation Award at the Japanese Society for Bacteriology
A medical student published a paper as first author
A paper by a project researcher was published in Life Science Alliance
A project researcher won a Poster Award at the Molecular Biology Society of Japan
Research findings by the lab's Project Assistant Professor at the time were published in Gene
ResearchResearch themes
Okuzaki Lab's mission is to advance single-cell analysis and human immunology. Centered on single-cell analysis, the lab also focuses on technological applications that connect basic research with clinical practice.
*Illustrative imageSingle-cell analysis of COVID-19
During the COVID-19 pandemic, the lab performed single-cell analysis of peripheral blood mononuclear cells (PBMCs) as a member of Team Osaka University, contributing to publications in major journals including Nature.
*Illustrative imageAntibodies that react to both viruses and self-antigens
In collaboration with many professors, the lab discovered a special antibody, "PA-N-CoV1804," that reacts to both viral antigens and self-antigens. It is found specifically in plasmablasts that differentiate and proliferate after infection, and the lab has reported findings on antibody responses in COVID-19 patients.
*Illustrative imageImmune features of encephalitis after vaccination
In patients who developed encephalitis after COVID-19 vaccination, the lab found a distinct immune signature in the peripheral immune system after onset. This cell population was not detected in healthy individuals or during remission, and is a unique myeloid subset.
*Illustrative imageNK cells in recovery from severe COVID-19
The lab investigated how NK cells diversify and undergo adaptive differentiation during recovery from severe COVID-19. It found that immature NK cells increase after vaccination, whereas in the recovery phase, adaptive NK cells with strong cytotoxic activity are induced.
MembersFaculty
Okuzaki Lab members consist of faculty, administrative assistants, technical assistants, graduate students, research students, medical students, undergraduate students in the Department of Health Sciences, visiting faculty and visiting researchers, and medical staff.As of 2026
- Project Associate ProfessorDaisuke Okuzaki
- Project Assistant ProfessorMohamad Al kadi
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Natural Killer Cell (NIH BioArt )” Courtesy of NIAID Ryan Kissinger / Public domain (cropped)
- Single-cell analysis of COVID-19: “Covid-19 SP - UTI V. Nova Cachoeirinha” Gustavo Basso / CC BY-SA 4.0 (cropped)
- Antibodies that react to both viruses and self-antigens: “Antibody IgG1 surface” Tokenzero / CC BY-SA 4.0 (cropped)
- Immune features of encephalitis after vaccination: “Japanese Encephalitis vaccine” Tech. Sgt. James Stewart / Public domain (cropped)
- NK cells in recovery from severe COVID-19: “Human Natural Killer Cell ( )” NIAID / CC BY 2.0 (cropped)
- Related lab (免疫機能ゲノミクス
（Functional Immunogenomics） ): “Chromatin (NIH BioArt )” Courtesy of NIAID Ryan Kissinger / Public domain (cropped) - Related lab (自然免疫学
（Host Defense） ): “Peritoneal fluid sediment in Wright Staining” Ajay Kumar Chaurasiya / CC BY-SA 4.0 (cropped) - Related lab (ヒト単一細胞免疫学
（Human Single Cell Immunology） ): “Lymph Node (NIH BioArt 304)” Courtesy of NIAID Ryan Kissinger / Public domain (cropped) - Related lab (実験免疫学
（Experimental Immunology） ): “HIV H9 T-cell II” National Institutes of Health (NIH) / Public domain (cropped)
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