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Tissue Immunology of Infection Lab
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The lab explores how immune networks are established in infected tissues.
AboutAbout the lab
Decoding the immune networks of infected tissues.
The Tissue Immunology of Infection Lab focuses on the immune networks that form in tissues infected by pathogens, and studies the mechanisms that control their formation, maintenance, and protective functions.
The immune response to a pathogen not only eliminates it but also builds immune defense mechanisms in the infected tissue, preparing it for the next infection.
On the other hand, some pathogens are not completely cleared from the body and persist for a long time as latent or persistent infections.
The lab investigates the immune memory that forms in mucosal and neural tissues after infection, as well as how latent and persistent infections are maintained and how they contribute to chronic disease, with the aim of leading to new strategies for prevention and treatment.
The lab belongs to the Immunology Group of the Immunology Frontier Research Center.
Key terms
- Immune memory
- Immune memory: the immune mechanism that forms after an infection and prepares the body for the next one. This lab focuses on how it is established in mucosal and neural tissues.
- Latent infection
- Latent infection: a state in which a pathogen is not completely cleared from the body and remains there for a long time.
- Mucosal tissue
- Mucosal tissue: tissue covering the inner surfaces of the body, such as in the intestines and reproductive organs.
ResearchResearch themes
The immune response to a pathogen not only eliminates the infecting pathogen but also forms immune defense mechanisms in the infected tissue, preparing it for the next infection. This lab focuses on the immune networks established in infected tissues and works to elucidate the mechanisms that control their formation, maintenance, and protective functions.
*Illustrative imageTissue immune memory and the maintenance of latent infection
The lab aims to elucidate how immune memory is established in mucosal and neural tissues after infection and how it protects against reinfection, leading to new prevention strategies. It also studies how the immune system is involved in maintaining latent and persistent infections by pathogens that remain in the body for long periods, with the aim of developing new treatment strategies.
*Illustrative imagePersistent infection and chronic disease
The lab aims to clarify how latent and persistent infections contribute to the onset and exacerbation of chronic diseases such as neurodegenerative diseases, autoimmune diseases, and cancer, deepening the understanding of disease mechanisms and finding clues to new treatments.
MembersFaculty
- Associate ProfessorNorifumi Iijima
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Infectiology - Herpes virus 1 -- Smart-Servier” Laboratoires Servier / CC BY-SA 3.0 (cropped)
- Tissue immune memory and the maintenance of latent infection: “Histology of normal fundic mucosa” Carrasco G, Corvalan AH / CC BY 3.0 (cropped)
- Persistent infection and chronic disease: “Ebola Virus Particles” NIAID / CC BY 2.0 (cropped)
- Related lab (免疫寄生虫学
（Immunoparasitology） ): “Toxoplasma parasites (tachyzoites) in a fibroblast host cell” Morne Arin (Ksena Longrin, previously known as Kseniia Bondarenko) / CC BY 4.0 (cropped) - Related lab (免疫微生物学
（Microbiology and Immunology） ): “Inflammed mucous layer of the intestinal villi depicting Celiac disease” www.scientificanimations.com / CC BY-SA 4.0 (cropped) - Related lab (実験免疫学
（Experimental Immunology） ): “HIV H9 T-cell II” National Institutes of Health (NIH) / Public domain (cropped) - Related lab (マラリア免疫学
（Malaria Immunology） ): “Malaria falciparum ring forms” Dr Graham Beards / CC BY-SA 4.0 (cropped)
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