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57 labs · 5 student voices
Other departments in School of Science ›Faculties at Hokkaido University ›
Toyoyuki Ose, Professor
0 student voices
The Structural Biochemistry Lab views life phenomena as a collection of chemical reactions and studies the reactions and interactions carried out by proteins. Its foundation is structural biology: examining the three-dimensional structures of biological macromolecules, and tracing how molecules interact and how enzymes convert substances. The phenomena it covers include the battle between the immune system and viruses, carcinogenesis and signal transduction pathways, unusual enzymatic reactions, and phenomena in which the positions of hydrogen atoms are key. By combining X-ray crystallography, neutron crystallography, electron microscopy, and NMR, the lab aims to connect the reactions carried out by proteins with life phenomena inside cells.
Tomoyasu Aizawa, Professor
0 student voices
The Protein Science Lab studies how proteins form three-dimensional structures and function. Even though the blueprint can be read from the genome, much remains unknown about the path from that blueprint to the formation of the correct shape and the exertion of function. Using genetic engineering techniques for mass production and NMR methods that can examine the structure and motion of molecules, the lab works with proteins from a wide range of organisms, from microbes and insects to humans. With the goal of freely controlling three-dimensional structure and function, the lab also collaborates with researchers across a wide range of fields to advance applications in medicine and industry.
Takayuki Nonoyama, Associate Professor
0 student voices
The Fusion Soft Matter Lab studies "soft matter": soft substances such as jelly and rubber. Soft matter has properties of both solids and liquids, and responds sensitively to stimuli and changes in its environment. Soft matter that is compatible with living tissue is attracting attention as a material for medicine and healthcare, including artificial tissue, regenerative medicine, and flexible sensors. The lab also uses natural polymers and biominerals in materials design, and works on creating materials that make use of the land and sea resources of Hokkaido.
Takayuki Kurokawa, Professor
0 student voices
The Transformative Soft Matter Lab researches the creation of functional polymer hydrogels. The lab repeats a cycle: investigating why the gels it makes have their functions, then using that knowledge to design the next gel. Along the way, technologies related to biomaterials and new ways of measuring physical properties have emerged. Through gels, students can learn from fundamentals to applications, such as understanding the friction and fatigue of tough double-network gels and creating gels for use in medical treatment.
Shinji Nakaoka, Professor
0 student voices
The Mathematical Biology Lab brings the methods of mathematical science and data analysis into biology in order to understand life phenomena. The lab uses mathematical models and simulations to test what cannot be understood from experimental and observational data alone. Themes are wide-ranging, including the ecosystems of gut and soil microbiota, analysis of medical data, and bioinformatics using comprehensive gene sequence data. Mathematics, informatics, and molecular biology are mainly involved, but the field you studied before joining the lab does not matter when you are assigned.
Hiroshi Hino, Professor
0 student voices
The Advanced Biological Regulation Science Lab studies the mechanisms of life and new medicines through the chemistry of sugars and glycans. Glycans display various patterns on the outside of cells, and, like blood types and serotypes, they serve as markers that represent the characteristics of an organism. Building on its own synthesis and analysis technologies, the lab develops "glycotyping," a technology that quickly captures the characteristics of glycan shapes. The lab aims to use the resulting technologies in materials science and life science, and also to connect them to the development of next-generation drugs.
Kenji Monde, Professor
0 student voices
The Chemical Biology Lab studies biomolecules such as nucleic acids, proteins, glycans, and lipids, aiming to understand them at the atomic level. In particular, the lab focuses on the difference between right-handed and left-handed forms of molecules (chirality) and is developing new analytical methods. It applies methods such as vibrational circular dichroism (VCD) to glycans and lipids, and examines the relationship between structure and biological function. The lab also works on developing enzyme inhibitors for lipid-related diseases such as obesity, Alzheimer's disease, atopic dermatitis, and cancer.
Hiroaki Adachi, Associate Professor
0 student voices
The lab studies how plants recognize pathogenic microorganisms and how they defend themselves. Plants have sensors called NLR immune receptors, which detect pathogen invasion and trigger immunity. Combining genome analysis, AI, and protein structure analysis, the lab predicts how receptors function from genome information and then tests those predictions. Pathogens, for their part, remodel plant tissues to settle in. The lab also makes these strategies visible under the microscope.
Ryota Uehara, Associate Professor
0 student voices
The lab studies cell division and changes in the number of genomes a cell carries (ploidy). Accurate cell division is essential for sustaining and passing on life, yet how a cell divides its contents equally and splits itself in two is still not understood. When the control of division goes wrong, the number of chromosomes changes and the properties of the cell change dramatically, which can also cause serious diseases such as cancer. Combining techniques for examining and manipulating cells, the lab aims to uncover, at the molecular level, the structure and workings of the "cellular apparatus" that supports division.
Takashi Kikukawa, Associate Professor
0 student voices
The lab studies the mechanisms of proteins that function when they receive light. The main research subject is microbial rhodopsin, a photoreceptor protein found in microorganisms. Using spectroscopy and electrochemical measurements, the lab follows how the shape of the protein changes step by step after light is applied. Based on the mechanisms uncovered, the lab also aims to give proteins new functions.
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