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Comprehensive Dentistry Lab
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A lab that handles clinical clerkships and residency while researching questions that arise in clinical practice.

AboutAbout the lab
Leading clinical education and turning questions from the field into research.
The Comprehensive Dentistry Lab (Division of Comprehensive Dental Care) manages clinical clerkships and clinical residency at Osaka University School of Dentistry and its Dental Hospital.
It also provides comprehensive care spanning multiple specialties and conducts research based on the various questions encountered in dental practice.
Its research covers methods for observing hard tissues, age-related changes in dentin, and systems for dental education.
Key terms
- Tomography
- A method of observing hard tissue in three dimensions using an ultra-high-voltage electron microscope.
- FIB/SEM
- A processing and observation method that uses a focused ion beam capable of nanoscale fabrication. Used to analyze the structure of undemineralized hard tissue.
- Advanced glycation end products (AGEs)
- Substances involved in age-related changes of dentin. The lab observes how they are deposited in teeth.
ResearchResearch themes
While managing clinical education and providing comprehensive care, the lab conducts research based on questions encountered in dental practice. Its main themes are methods for observing hard tissues, age-related changes in dentin, and systems for dental education. The description on the research introduction page is based on information from around 2021.
*Illustrative imageDeveloping methods to observe hard tissue
Using tomography with an ultra-high-voltage electron microscope and FIB/SEM, the lab examines the structure of undemineralized hard tissue, which has been difficult to observe until now. It applies these methods to observing the bonding interface between dental restorative materials and tooth structure, and the interface between implants and bone.
*Illustrative imageAge-related changes and glycation of dentin
The lab studies the deposition in teeth of advanced glycation end products (AGEs), which are involved in age-related changes of dentin, along with discoloration and embrittlement of the tissue, aiming to apply the findings in clinical practice. It has become clear that these changes are also linked to how dentin is affected by metabolic disorders such as diabetes and to the mechanisms by which chronic caries develops.
*Illustrative imageResearch on dental education systems
From its position of managing clinical education at the School of Dentistry and its Dental Hospital, the lab also develops systems that support more effective learning.
MembersFaculty
- Associate ProfessorTakenori Nozaki
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Hospital Dental Engine” Ptrump16 / CC BY-SA 4.0 (cropped)
- Developing methods to observe hard tissue: “Platform switch” DRosenbach / CC BY-SA 3.0 (cropped)
- Age-related changes and glycation of dentin: “Cross sections of teeth labels” Ian Furst, Goran tek-en / CC BY-SA 3.0 (cropped)
- Research on dental education systems: “New dental clinic at CEP ( )” University of the Fraser Valley / CC BY 2.0 (cropped)
- Related lab (Oral and Maxillofacial Surgery Lab): “Dental instruments by Roboz Tech Surgical” RobozTech / CC BY-SA 4.0 (cropped)
- Related lab (Pediatric Dentistry Lab): “Streptococcus mutans Gram” Y tambe / CC BY-SA 3.0 (cropped)
- Related lab (Oral and Maxillofacial Pathology Lab): “Stained microscope slide” Waughd / CC BY-SA 4.0 (cropped)
- Related lab (Systematic Anatomy and Neuroanatomy Lab): “Brain Anatomy Model ( )” YVC Biology Department / CC BY 2.0 (cropped)
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