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Beyond Cell Reborn Lab
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A lab studying the transport of molecules within cells and autophagy.
AboutAbout the lab
Research on membrane trafficking and autophagy
The Beyond Cell Reborn Endowed Chair (Yoshimori Lab) studies membrane trafficking, the mechanism by which molecules move around inside cells.
In particular, the lab focuses on autophagy, the process by which cells break down components they no longer need.
Taking advantage of its place in the medical school, the lab collaborates with clinical departments to conduct research toward the prevention and treatment of diseases involving autophagy.
Key terms
- Membrane trafficking
- A transport system that exchanges molecules between membrane organelles through membrane movements such as fission, movement, elongation, and fusion
- Autophagy
- A mechanism in which unneeded molecules and structures inside the cell are enclosed in a membrane and degraded in lysosomes
NewsLab news
The Yoshimori Lab moved to the Beyond Cell Reborn Endowed Chair in the Division of Health Sciences
Reported in Nature Cell Biology the mechanism that controls the production of exosomes that promote aging
Reported in The EMBO Journal a new receptor in the mechanism that degrades the Golgi apparatus
Reported in PNAS a factor involved in the quality control of mitochondria and lysosomes
Reported in EMBO reports a factor involved in the repair of damaged lysosomes
ResearchResearch themes
The lab's theme is to clarify the molecular mechanisms of membrane trafficking and its roles in the living body. Inside eukaryotic cells, molecules move between various membrane organelles, forming a transport network, and the breakdown of this network causes a variety of diseases.
*Illustrative imageResearch on the autophagy pathway
Membrane trafficking has several pathways. The lab initially also studied the endocytosis pathway, but it now focuses on the autophagy pathway, using cutting-edge technologies such as imaging.
*Illustrative imageResearch linked to disease prevention and treatment
Taking advantage of its place in the medical school, the lab collaborates with clinical departments to carry out original research toward the prevention and treatment of diseases involving autophagy.
MembersFaculty
The members of the Yoshimori Lab consist of faculty members, doctoral students, technical assistants, and a secretary.As of 2025
- Project ProfessorTamotsu Yoshimori
- Project ProfessorTakashi Maekawa
- Project Associate ProfessorAkiko Kuma
- Project Assistant ProfessorSatoshi Minami
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Cell-universe” Bibeh100 / CC BY-SA 4.0 (cropped)
- Research on the autophagy pathway: “Endocytosis, vesicle traffic, protist” Sina Adl / CC BY 4.0 (cropped)
- Research linked to disease prevention and treatment: “The Process of Autophagy” Sadafjavaidkhan / CC BY-SA 4.0 (cropped)
- Related lab (癌幹細胞制御学): “T cells in a squamous cell carcinoma” NIH Image Gallery / Public domain (cropped)
- Related lab (医療経済・経営学): “Hospital Reception in Lagos” Beendy234 / CC0 (cropped)
- Related lab (未来医療学): “Stem-cells-vial-ama-regenerative-medicine” [<a href="https://www.amaskincare.com/about/alice-pien-md-medical-director/">Alice Pien, MD</a>] / CC BY-SA 4.0 (cropped)
- Related lab (癌免疫学): “Laboratory (3)” Linda Bartlett (Potographer) / Public domain (cropped)
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