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Cancer Immunology Lab
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A lab developing cancer immunotherapy that targets WT1.
AboutAbout the lab
Developing evidence-based cancer immunotherapy
The Endowed Chair of Cancer Immunology pursues basic and clinical research toward new cancer immunotherapies that are gentle on the body and have few side effects.
Centered on the WT1 peptide vaccine, which targets the cancer antigen WT1, the lab investigates ways to enhance the vaccine's effect and its potential as a preventive vaccine.
The lab conducts its research in collaboration with other related departments, many clinicians, and researchers overseas.
It is an endowed chair at the Borderless Design Medical Research Center, Division of Health Sciences, Graduate School of Medicine, Osaka University.
Key terms
- WT1
- The antigen this lab identified as a cancer antigen. It is expressed universally in cancers and is essential for cancer development
- WT1 peptide vaccine
- A treatment that uses the cancer antigen WT1 as a marker to attack only cancer cells, with few side effects
- Preventive vaccine
- A vaccine given preventively before a person develops cancer. The current therapeutic vaccines are given to patients who have been diagnosed with cancer
ResearchResearch themes
The lab aims to develop treatments that attack only cancer cells and cause few side effects, by targeting the cancer antigen WT1, which is expressed universally in cancers. Its work spans mouse model studies through clinical trials, and covers preventive vaccines as well as therapeutic vaccines.
*Illustrative imageWT1, a promising cancer antigen
Cancer immunotherapy became widely known with the advent of immune checkpoint inhibitor therapy in the 2010s. WT1, which this lab identified as a cancer antigen, is expressed universally in cancers and is an antigen essential for cancer development.
*Illustrative imageMethods to enhance vaccine efficacy
Using mouse models, the lab develops strategies to enhance vaccine efficacy, such as combination with adjuvants, chemotherapeutic agents, molecularly targeted drugs, and helper peptides, and has already conducted clinical trials. It also analyzes samples from treated patients in detail.
From therapeutic vaccines to preventive vaccines
Because WT1 is also expressed in cancer stem cells and precancerous lesions, it is promising as a target for preventive vaccines, in addition to the current therapeutic vaccines given to patients diagnosed with cancer. The lab has found efficacy in mice and is advancing clinical trials in humans.
MembersFaculty
- Professor, Endowed ChairHaruo Sugiyama
- Associate Professor, Endowed ChairHiroko Nakajima
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Laboratory (3)” Linda Bartlett (Potographer) / Public domain (cropped)
- WT1, a promising cancer antigen: “Processing of tumor antigens recognized by CD8+ T cells” UCLLICRBRU / CC BY-SA 4.0 (cropped)
- Methods to enhance vaccine efficacy: “Syringe, Vaccine Bottle, and Globe ( )” NIAID / CC BY 2.0 (cropped)
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