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Cancer Stem Cell Regulation Lab
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The lab analyzes immune responses against cancer and develops immunotherapies that target cancer stem cells.
AboutAbout the lab
Analyzing immune responses to cancer to target cancer stem cells.
The Cancer Stem Cell Regulation endowed department analyzes immune responses against cancer cells and researches the development of immunotherapies that target cancer cells, especially cancer stem cells.
Centered on peptide vaccine therapy targeting WT1, which is expressed in many cancers, the lab continues research to enhance its effect from both basic and clinical perspectives.
Recently, to overcome the decline in quality of infused T cells, the lab has also been working on producing T cells that exhibit and maintain high function.
It is an environment where data obtained in mice can be verified using human specimens collected in clinical trials and drug-approval trials.
Key terms
- WT1
- A protein expressed in many cancers that serves as a target antigen for cancer immunotherapy
- Peptide vaccine
- A therapy that uses WT1 peptides (short fragments made of linked amino acids) to boost the immune response against cancer
- TCR
- The T cell receptor, a receptor on the surface of T cells that recognizes targets
- avidity
- An indicator of how strongly a TCR binds to its target
ResearchResearch themes
Centered on WT1, a target antigen for cancer immunotherapy, the lab investigates the mechanisms of immune responses against cancer, aiming to strengthen therapies. It is also developing new T cell therapies capable of exerting strong antitumor effects.
*Illustrative imageEnhancing the effect of the WT1 peptide vaccine
Using human specimens and mouse models, the lab analyzes the mechanisms of immune responses specific to cancer antigens, aiming to strengthen WT1-targeted cancer immunotherapy. Based on the discovery that WT1 can serve as a target antigen, it has conducted clinical trials of peptide vaccines.
*Illustrative imageSearching for genes that control T cell differentiation
The lab searches for candidate genes that control T cell differentiation and clarifies how they function in T cells, aiming to develop powerful new T cell therapies. It has reported that vitamin A metabolic signaling is a target for memory T cells.
*Illustrative imageIsolating and applying high-avidity TCRs
The lab has independently created 2D3 cells, in which TCR avidity can be evaluated using GFP expression as an indicator. It is advancing research on applying TCRs isolated with these cells to TCR-T cell therapy.
MembersFaculty
The Cancer Stem Cell Regulation endowed department consists of an endowed-department Professor and an endowed-department Lecturer.As of 2026
- Professor, Endowed ChairYoshihiro Oka
- Lecturer, Endowed ChairSoyoko Morimoto
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “T cells in a squamous cell carcinoma” NIH Image Gallery / Public domain (cropped)
- Enhancing the effect of the WT1 peptide vaccine: “Protein WT1 PDB 1xf7” Emw / CC BY-SA 3.0 (cropped)
- Searching for genes that control T cell differentiation: “The differentiation of CD8+ T cells and different CD8+ subsets” Vita Golubovskaya, Lijun Wu / CC BY 4.0 (cropped)
- Isolating and applying high-avidity TCRs: “An MHC tetramer binding to T-cell receptors (left), and an MHC molecule on the surface of an antigen presenting cell binding to T-cell receptors (right)” Bethmkthomas / CC BY-SA 4.0 (cropped)
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