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Anesthesiology and Intensive Care Medicine Lab
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A lab that tackles the mechanisms of breathing and the brain from the front lines of anesthesia and intensive care.
AboutAbout the lab
Driven by the curiosity to resolve clinical questions
The Anesthesiology and Intensive Care Medicine lab conducts research on the lungs in relation to mechanical ventilation management, as well as on the relationship between anesthesia and the brain.
Curiosity about resolving questions that arise in clinical practice is the driving force of its research, which is carried out in divisions such as pulmonary physiology and neurophysiology.
All areas related to anesthesia are objects of study, including surgical anesthesia, intensive care, palliative pain care, and labor analgesia management.
Key terms
- ARDS
- Acute respiratory failure that arises from a variety of conditions, in which increased permeability of the pulmonary vessels causes non-cardiogenic pulmonary edema.
- Positive end-expiratory pressure (PEEP)
- Positive pressure applied to the lungs during exhalation. It has conventionally been considered impossible to generate without a ventilator.
- Postoperative delirium
- A disturbance of consciousness with reduced attention, or a perceptual disturbance with changes in cognition, occurring after surgery or anesthesia.
NewsLab news
Assistant Professor Taenaka received the Best Abstract Award (The Pleural Pressure Working …)
A paper by Assistant Professor Kinishi and colleagues was published in Scientific Reports
Assistant Professor Taenaka received the Excellent Presentation Award (73rd Annual Meeting of the Japanese Society of Anesthesiologists)
Research results on lung stress mapping were published in the American Journal of Respiratory and Critical Care Medicine
A paper by Professor Takeshi Yoshida was published in Intensive Care Medicine
ResearchResearch themes
Research is organized into divisions such as pulmonary physiology, neurophysiology, and pain relief, and is driven by curiosity about resolving questions that arise in clinical practice. The Pulmonary Physiology Division aims to provide individualized respiratory management suited to each patient during surgical anesthesia and ICU care, while the Neurophysiology Division investigates the mechanisms of postoperative delirium and the effects of anesthetics on the developing brain.
*Illustrative imageTechnology to Visualize Lung Injury Risk
In joint research with the Department of Radiology and a company, the lab is working to establish a technology that visualizes information on lung stress throughout the lungs. The goal is to evaluate the amount, location, and pattern of regions at risk of lung injury, and to predict prognosis using artificial intelligence.
*Illustrative imageGenerating Positive End-Expiratory Pressure Without a Ventilator
In joint research with the Graduate School of Engineering Science and a company, the lab is developing a single-use connector for breathing circuits that can generate positive end-expiratory pressure (PEEP) without a ventilator. The aim is to help patients who depend on long-term mechanical ventilation be weaned earlier.
*Illustrative imageSpontaneous Breathing–Related Lung and Diaphragm Injury
Using rabbit and pig ARDS models, the lab investigated the possibility that strong spontaneous breathing can worsen lung injury even when patients are managed with low tidal volume and low airway pressure, and thereby proposed the concept of "spontaneous breathing–related lung injury." It is now working to clarify the mechanism and establish treatments.
*Illustrative imageTechniques to Prevent Lung Collapse During Surgery
The lab is examining whether a recruitment maneuver, which inflates the lungs at a pressure higher than the positive pressure normally delivered during general anesthesia, can reduce postoperative pulmonary complications. In joint research with Toho University Ohashi Medical Center, it is conducting a comparative study of laparoscopic surgeries performed in the Trendelenburg position.
MembersFaculty
The members of the Anesthesiology and Intensive Care Medicine lab consist of full-time physicians, residents in specialty training, graduate students, and project researchers.As of 2026
- ProfessorTakeshi Yoshida
- Lecturer, Deputy DirectorYukiko Koyama
- Lecturer, Ward ChiefYoichi Matsuda
- LecturerMitsuhiro Matsumoto
- LecturerAkira Iura
- LecturerShunsuke Yamamoto
- Project LecturerAiko Tanaka
- Project LecturerTomonori Yamashita
- Assistant Professor / Chief of Outpatient ClinicAyako Takahashi
- Assistant ProfessorYuki Kinishi
- Assistant ProfessorHirofumi Iwata
- Assistant ProfessorYusuke Enotani
- Assistant ProfessorAkika Hashimoto
- Assistant ProfessorYu Matsumoto
- Assistant ProfessorAi Yamamura
- Assistant ProfessorShun Ishigaki
- Assistant ProfessorHiroki Taenaka
- Assistant ProfessorTomoyuki Morioka
- Assistant ProfessorDaisuke Ujimoto
- Project Assistant ProfessorMegumi Harima
- Project Assistant ProfessorMoe Furude
- Project Assistant ProfessorMariko Kuroda
- Project Assistant ProfessorTomoo Yuba
- Project Assistant ProfessorAyaka Ikemura
- Project Assistant ProfessorYuki Nakai
- Project Assistant ProfessorHiroshi Horiike
- Project Assistant ProfessorYutaka Iki
- Project Assistant ProfessorRyutaro Nishio
- Project Assistant ProfessorNaomi Sakai
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Smile Train Surgery DVIDS126459” Staff Sgt. Brendan Stephens / Public domain (cropped)
- Technology to Visualize Lung Injury Risk: “HRCT Chest Scan Showing COVID-19 Lung Infection (Ground-Glass Opacities)” Goleisureintl / CC BY 4.0 (cropped)
- Generating Positive End-Expiratory Pressure Without a Ventilator: “Respiratory therapy” Ashashyou / CC BY-SA 3.0 (cropped)
- Spontaneous Breathing–Related Lung and Diaphragm Injury: “Human diaphragm” Anatomography / CC BY-SA 2.1 jp (cropped)
- Techniques to Prevent Lung Collapse During Surgery: “US Navy 120117-N-MH561-116 Lt. Jacob Pletcher induces general anesthesia on a patient about to undergo surgery in the operating room of the Nimitz” U.S. Navy photo by Capt. Jaime A. Quejada / Public domain (cropped)
- Related lab (Respiratory Medicine and Clinical Immunology Lab): “Miner spirometry ( )” National Institute for Occupational Safety and Health (NIOSH) from USA / Public domain (cropped)
- Related lab (Cardiovascular Medicine Lab): “Mammal heart model 04- FMVZ USP-06” Wagner Souza e Silva / CC BY-SA 4.0 (cropped)
- Related lab (Molecular Neuroscience Lab): “Neuron in the microchannel of hydrogel implant” Wisstock / CC BY 4.0 (cropped)
- Related lab (Emergency Medicine Lab): “Not-Intubation” User:MrArifnajafov / CC BY-SA 3.0 (cropped)
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