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Radiation Chemical Biology Lab
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A lab studying drugs that treat cancer with alpha radiation, and the functions of sugar- and lipid-related molecules.
AboutAbout the lab
Targeted alpha therapy and functional analysis of sugar- and lipid-related molecules.
The Radiation Chemical Biology Lab studies drug development for targeted alpha therapy (TAT) and the functional analysis of sugar- and lipid-related molecules.
Targeted alpha therapy is a drug-based treatment that delivers nuclides emitting high-energy alpha particles to cancer cells and kills them, and it is attracting attention as a new treatment for intractable cancers.
The lab develops drug candidate compounds labeled with astatine-211 and conducts research with a view to a first-in-human clinical trial.
In addition, in collaboration with synthetic organic chemists, the lab creates fluorescently labeled bioactive molecules and investigates the functions of sugar- and lipid-related molecules involved in diseases such as infections, cancer, and diabetes.
Key terms
- Targeted alpha therapy (TAT)
- A drug-based treatment that delivers nuclides emitting high-energy alpha particles to cancer cells and kills them
- Astatine-211
- A short-lived nuclide that emits alpha particles. This lab uses it to label drug candidate compounds
- FIH trial
- A first-in-human trial, the clinical trial stage in which a new drug is administered to humans for the first time
NewsLab news
Joint research with Prof. Kato of the Graduate School of Medicine and colleagues published in Pharmaceutics
Book Gangliosides: Methods and Protocols published, with the lab contributing one chapter
Joint research with Tongji University published in Journal of Nanobiotechnology
Joint research published in Journal of Radioanalytical and Nuclear Chemistry
Book Glycoscience: A Global Roadmap 2025 from Japan published, with the lab contributing one chapter
ResearchResearch themes
Targeted alpha therapy is attracting attention as a new treatment for intractable cancers. This lab works on developing drugs for this therapy and on analyzing the functions of sugar- and lipid-related molecules involved in disease.
*Illustrative imageDevelopment of drugs for targeted alpha therapy
The lab is developing drug candidate compounds labeled with astatine-211, a short-lived nuclide that emits alpha particles. The research looks ahead to a first-in-human (FIH) clinical trial.
*Illustrative imageFunctional analysis of sugar- and lipid-related molecules
In collaboration with synthetic organic chemists, the lab creates fluorescently labeled bioactive molecules. It analyzes, from the viewpoint of molecular chemistry, the functions of sugar- and lipid-related molecules involved in diseases such as infections, cancer, and diabetes.
MembersFaculty
The members of the Radiation Chemical Biology Lab consist of faculty, project researchers, doctoral, master's, and undergraduate students, short-term exchange students, technical assistants, and administrative assistants.As of 2026
- ProfessorKazuya Kabayama
- Project Assistant ProfessorXuhao Huang
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Radiochemistry Laboratory ( )” IAEA Imagebank / CC BY 2.0 (cropped)
- Development of drugs for targeted alpha therapy: “Astatine (Element - 85)” James St. John / CC BY 2.0 (cropped)
- Functional analysis of sugar- and lipid-related molecules: “Green Fluorescence Microscopy” Jamil Baza / CC BY 4.0 (cropped)
- Related lab (Radiation Science Lab): “Radiation Assessment Detector for Curiosity Rover” NASA / Public domain (cropped)
- Related lab (Radiation Biochemistry Lab): “Isotope laboratory at the National Institutes of Health ( )” NIH Image Gallery from Bethesda, Maryland, USA / Public domain (cropped)
- Related lab (Natural Products Organic Chemistry Lab): “Gram negative cell wall-id” Gram_negative_cell_wall.svg: Jeff Dahl derivative work: 24Adrianus (talk) / CC BY-SA 3.0 (cropped)
- Related lab (Analytical Chemistry Lab): “Working in analytical chemistry 5” Martin Schaier / CC BY 4.0 (cropped)
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