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Radiation Biochemistry Lab
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A lab that radiolabels molecules with radionuclides to explore their potential as nuclear medicine therapeutics.
AboutAbout the lab
Labeling radionuclides to explore nuclear medicine therapeutics.
The Radiation Biochemistry Lab aims to develop nuclear medicine therapeutics by labeling molecules of various sizes with short-lived radionuclides and evaluating their functions.
The lab also analyzes the function of LAT1, an amino acid transporter whose expression is specifically induced in cancer cells, in order to clarify why this molecule is expressed in cancer and to help develop better therapeutics.
In collaboration with the Graduate School of Medicine, the Graduate School of Engineering, the Institute for Radiation Sciences, and the Research Center for Nuclear Physics, the lab is involved in every step, from producing and separating nuclides to synthesizing and labeling compounds and evaluating them in cells and experimental animals.
Regardless of which undergraduate faculty students come from, the lab values learning a variety of experimental methods and discovering one's own aptitude.
Key terms
- Nuclear medicine therapeutics
- Therapeutics in which a substance carrying a highly cytotoxic radioisotope is recognized by a molecular target
- Radioisotope
- An atom that emits radiation. In this lab, it is attached to molecules that become drugs
- Amino acid transporter
- A transporter that cells use to take up amino acids. LAT1 is the cancer-type transporter and is overexpressed in cancer tissue
NewsLab news
Graduate school admissions guidelines published
A paper by a doctoral student has been accepted
A paper by the research group has been accepted
A paper by an undergraduate student has been accepted
A joint research project has been announced in a press release
ResearchResearch themes
Aiming at applications as nuclear medicine therapeutics, the Radiation Biochemistry Lab labels substances ranging from small and medium-sized molecules to macromolecules with short-lived radionuclides and evaluates their functions. The lab also analyzes the function of LAT1, an amino acid transporter whose expression is specifically induced in cancer cells.
*Illustrative imageAmino acid derivatives for nuclear medicine therapeutics
The lab is developing nuclear medicine therapeutics that target amino acid transporters induced in cancer cells as molecular targets. It synthesizes amino acid derivatives recognized by a specific transporter and labels them with highly cytotoxic radioisotopes, aiming at their use as therapeutics.
*Illustrative imageQuality of nuclear medicine therapeutics
Even when a nuclear medicine therapeutic has been developed, its quality must be stable. The lab aims to confirm the stability of labeled substances and refine them to a level at which they can be transferred to industry.
*Illustrative imageBiological effects of ingested radioisotopes
There are many types of radiation, including alpha rays, beta rays, gamma rays, X-rays, and neutron beams. The lab in particular evaluates the effects of radioisotopes to which people are exposed in medical settings and in the natural environment.
*Illustrative imageAnalysis of LAT1, an amino acid transporter in cancer cells
LAT1 is said to be a cancer-type amino acid transporter, but many aspects of the mechanisms that control its expression remain unknown. The lab aims to clarify, using comprehensive analysis methods, why it is overexpressed in cancer tissue.
MembersFaculty
The members of the Radiation Biochemistry Lab consist of faculty, researchers, doctoral, master's, and undergraduate students, and collaborators.As of 2026
- ProfessorKazuko Kaneda-Nakashima-Nakashima
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Isotope laboratory at the National Institutes of Health ( )” NIH Image Gallery from Bethesda, Maryland, USA / Public domain (cropped)
- Amino acid derivatives for nuclear medicine therapeutics: “Radiopharmaceutical” Sahehco / CC BY-SA 4.0 (cropped)
- Quality of nuclear medicine therapeutics: “Radiochemistry Laboratory ( )” IAEA Imagebank / CC BY 2.0 (cropped)
- Biological effects of ingested radioisotopes: “Alpha radiation in a cloud chamber” Nuledo / CC BY-SA 4.0 (cropped)
- Analysis of LAT1, an amino acid transporter in cancer cells: “Breast cancer cell (2)” Unknown photographer / Public domain (cropped)
- Related lab (Radiation Chemical Biology Lab): “Radiochemistry Laboratory ( )” IAEA Imagebank / CC BY 2.0 (cropped)
- Related lab (Radiation Science Lab): “Radiation Assessment Detector for Curiosity Rover” NASA / Public domain (cropped)
- Related lab (Isotope Chemistry Lab): “Radio-Chemist closing a hot cell to proect themselves from radiation” Talzir / CC BY-SA 4.0 (cropped)
- Related lab (Precision Polymer Science Lab): “Plastic pellets for injection molding” Teemeah / CC BY-SA 3.0 (cropped)
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