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Polymer Biotechnology Lab
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The lab studies foods and pharmaceuticals through the physical properties and structures of biological macromolecules.
AboutAbout the lab
Using measurement to uncover the properties of biological macromolecules.
The lab studies the physical properties, structures, and functions of biological macromolecules (biopolymers) such as proteins, nucleic acids, and polysaccharides, which make up foods, gene therapy vectors, and biopharmaceuticals.
Its goal is to contribute to the creation of high-quality, safe foods and pharmaceuticals.
The lab carries out comprehensive analysis that combines well-established physicochemical methods, such as analytical ultracentrifugation and viscoelasticity measurement, with cutting-edge measurement techniques such as mass spectrometry.
On the lab's website, it is introduced under the name "Uchiyama Lab."
Key terms
- Adeno-associated virus (AAV) vector
- A type of viral vector used in gene therapy as a means of delivering disease-treating genes into the body.
- Analytical ultracentrifugation
- An analytical method that this lab is developing to analyze the distribution of molecular size and density of AAV.
- Mass spectrometry
- A measurement technique used to examine the structure of the proteins that make up AAV and changes in the chemical structure of biopharmaceuticals.
- Protein aggregates
- Clumps formed when stressed proteins gather together. They have been pointed out as potentially immunogenic, so accurate quantification is needed.
ResearchResearch themes
The lab aims to understand the physical properties, structures, and functions, in solutions and gels, of the biological macromolecules that make up foods, gene therapy vectors, and biopharmaceuticals. To do so, it carries out comprehensive analysis using physicochemical methods such as analytical ultracentrifugation and viscoelasticity measurement, together with measurement techniques such as mass spectrometry.
*Illustrative imageAnalysis and manufacturing of viral vectors for gene therapy
Using mass spectrometry, analytical ultracentrifugation, and other methods, the lab develops analytical techniques that clarify the characteristics of adeno-associated virus (AAV) vectors and similar vectors. It is also researching manufacturing processes that increase the yield and purity of recovered AAV.
*Illustrative imagePhysical property research for high-quality biopharmaceuticals
The lab develops methods to accurately measure aggregates of proteins, the main components of biopharmaceuticals, and methods to reduce aggregation. It also works on analysis of chemical structures and higher-order structures, and on research into stable formulations and container and packaging materials.
MembersFaculty
The members of the lab are faculty, project faculty and researchers, special researchers, doctoral, master's, and undergraduate students, technical assistants, and administrative assistants.As of 2024
- ProfessorSusumu Uchiyama
- Associate ProfessorTetsuo Torisu
- Assistant ProfessorYuki Yamaguchi
- Project Associate ProfessorTakuya Yamane
- Project Associate ProfessorYasuo Tsunaka
- Project Assistant ProfessorRisa Shibuya
- Project LecturerMitsuko Fukuhara
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “TOF mass spectrometer June2007” Mwillett4000 / Public domain (cropped)
- Analysis and manufacturing of viral vectors for gene therapy: “Adeno-associated viruses” Dr Graham Beards Talk / CC BY-SA 3.0 (cropped)
- Physical property research for high-quality biopharmaceuticals: “Protein Aggregation” Lisa96liu (talk) / Public domain (cropped)
- Related lab (生物資源工学領域): “Secondary Ion Mass Spectrometer (SIMS) Tube - DPLA - 2a22bbd17e faf628d93a557 (page 2)” Honig, Richard E. (Richard Edward) / CC BY 4.0 (cropped)
- Related lab (代謝情報工学講座［情報科学研究科］
): “Yeast culture plate” BMC bildes / CC BY-SA 3.0 (cropped) - Related lab (バイオ情報計測学講座
[情報科学研究科] ): “Thermo - Finnigan LCQ Mass Spectrometer ( )” Kitmondo Marketplace / CC BY 2.0 (cropped) - Related lab (構造有機化学領域): “Chemistry Experiment 3D” TeWeBs / CC BY-SA 4.0 (cropped)
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