Metabolic Information Engineering Lab [Graduate School of Information Science and Technology]

AboutAbout the lab

Combining wet-lab and computational approaches to drive innovation in biotechnology.

The Metabolic Information Engineering Lab develops methods to improve cells to an optimal state for microbial production of useful substances.
Using genome-scale metabolic models that cover the whole cell, the lab designs desirable metabolic states on a computer and then breeds strains that realize them.
Through metabolic flux analysis using 13C stable isotope labeling, the lab captures the flow of cellular metabolism experimentally and combines it with computational analysis.
On the lab's website, it is also introduced under the name "Shimizu Lab."

ResearchResearch themes

The lab views cellular metabolism as a multi-step reaction process and has advanced metabolic engineering, which rationally optimizes metabolism. It has developed genome-wide metabolic reaction models and in silico metabolic design methods, demonstrated their effectiveness through genetic manipulation, and evaluates cell states by metabolic flux analysis using 13C stable isotope labeling.

VoicesStudent voices

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