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Basic and Applied Molecular Biotechnology Lab
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The lab discovers outstanding functions of microorganisms, clarifies the mechanisms behind them, and applies them to improve daily life.
AboutAbout the lab
Discovering microbial power, clarifying its mechanisms, and putting it to use.
The lab discovers the outstanding functions of microorganisms such as bacteria, yeasts, and molds, and clarifies the mechanisms that support those functions at the cellular, molecular, and atomic levels.
Based on its findings, the lab aims to improve microbial functions and apply them to daily life and a sustainable society.
Undergraduates are assigned to the lab in their fourth year (graduate school: Division of Food Science and Biotechnology, Graduate School of Agriculture).
Key terms
- Commensal bacteria
- Microbes that always live on surfaces such as the body or plants
- Membrane vesicles
- Small sacs formed when pieces of the cell membrane pinch off. They carry substances inside and release them outside the cell
- Alginate
- A polysaccharide abundant in brown algae such as kelp
ResearchResearch themes
The lab aims to uncover outstanding microbial functions, clarify their mechanisms, and apply them to daily life. Its methods include omics analysis, molecular biology, cell biology, structural biology, and synthetic biology.
*Illustrative imageCommensal bacteria and their hosts
The lab studies how commensal bacteria that always live in organisms, such as gut bacteria, act on the mucus layer of animals, with the aim of helping beneficial microbes colonize. It also studies how fermented foods are made, for example the early response of natto bacteria to soybeans.
*Illustrative imageShape changes created by bacterial membranes
The lab found bacteria that produce membrane vesicles resembling exosomes, which enclose polysaccharides inside. It also discovered bacteria that degrade part of their membrane on surfaces such as soybeans to form 'cave'-shaped structures. The lab studies the functions of these structures and how they form.
*Illustrative imageBacteria that take in whole polysaccharides
One bacterium does not break down alginate outside the cell but takes it in directly through a 'body cavity' on the cell surface. The lab studies the uptake mechanism and chemotaxis toward polysaccharides, aiming to apply them to polysaccharide utilization.
Recovering metals with microbes
The lab analyzes how microbes take up metals and is working to apply this to rare metal recovery. It also studies the structure and function of a microbial metalloprotein that inhibits the proliferation of cancer cells.
MembersFaculty
The members of the lab consist of faculty and students in the doctoral program, master's program, and undergraduate program.
- ProfessorWataru Hashimoto
- Associate ProfessorKohei Ogura
- Assistant ProfessorTeisuke Takita
- Assistant ProfessorHaruka Higashi
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Observing Bacteria with a Microscope” M Joko Apriyo Putro / CC0 (cropped)
- Commensal bacteria and their hosts: “Selfmade Natto” Carstor / CC BY 3.0 (cropped)
- Shape changes created by bacterial membranes: “Halanaerobium praevalens GSLᵀ - scanning electron micrograph” Natalia Ivanova , Johannes Sikorski , Olga Chertkov , Matt Nolan , Susan Lucas , Nancy Hammon , Shweta Deshpande , Jan-Fang Cheng , Roxanne Tapia , Cliff Han , Lynne Goodwin , Sam Pitluck , Marcel Huntemann , Konstantinos Liolios , Ioanna Pagani , Konstantinos Mavromatis , Galina Ovchinikova , Amrita Pati , Amy Chen , Krishna Palaniappan , Miriam Land , Loren Hauser , Evelyne-Marie Brambilla , K. Palani Kannan , Manfred Rohde , Brian J. Tindall , Markus Göker , John C. Detter , Tanja Woyke , James Bristow , Jonathan A. Eisen , Victor Markowitz , Philip Hugenholtz , Nikos C. Kyrpides , Hans-Peter Klenk and Alla Lapidus / CC BY 4.0 (cropped)
- Bacteria that take in whole polysaccharides: “Alginsäure” NEUROtiker / Public domain (cropped)
- Related lab (Agricultural Product Manufacturing Lab): “Production of cheese 1” MatthiasKabel / CC BY-SA 3.0 (cropped)
- Related lab (Food Physiology and Function Lab): “Food-healthy-vegetables-potatoes ( )” www.Pixel.la Free Stock Photos / CC0 (cropped)
- Related lab (Bioorganic Chemistry Lab): “Chemical Compound ( )” National Center for Advancing Translational Sciences from Bethesda, MD / Public domain (cropped)
- Related lab (Molecular Biology and Bioresponse Lab): “Zinc foils” Mauro Cateb / CC BY-SA 3.0 (cropped)
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