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シグナル薬理学
Showing the original Japanese · View translation
多くの薬の標的GPCRの信号を見えるようにして、次の薬を生み出す研究室。
AboutAbout the lab
GPCRの信号を、理解し、操る。
GPCRは
シグナル薬理学分野
新しい
Key terms
- GPCR
- Gタンパク質共役型受容体。
細胞膜に あり、 ホルモンなどの 信号を 細胞の 中に 伝える 受容体 - Gタンパク質
- GPCRから
信号を 受け取り、 細胞の 中に 伝える タンパク質 - DREADD
- 人工の
薬だけに 反応するように 作り変えた 受容体。 狙った 信号だけを 起こせる - 分
子動力学シミュレーション - 原子や
分子の 動きを コンピュータで 計算し、 タンパク質の ふる まいを 再現する 方法
ResearchResearch themes
GPCRと
*Illustrative imageGPCRの活性化を測る方法
Gqや
*Illustrative imageGPCRとGタンパク質の対応表
リガンドが
*Illustrative imageG12の信号の働きを個体で調べる
G12と
*Illustrative imageGPCRの動きを計算と1分子で見る
分
MembersFaculty
- Professor井上 飛鳥
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “202304 G protein-coupled receptor” DataBase Center for Life Science (DBCLS) / CC BY 4.0 (cropped)
- GPCRの
活性化を 測る 方法: “GPCR structure” Tae Young Choi / CC BY-SA 3.0 (cropped) - GPCRと
Gタンパク質の 対応表: “G Protein rezeptor-CS” Peter Wolber & Jan Štěch / CC BY-SA 4.0 (cropped) - G12の
信号の 働きを 個体で 調べる : “Vascular-endothelial-growth-factor-vegf-signaling-2011” Acknowledgement: Illustration by David S. Goodsell, RCSB Protein Data Bank. doi: 10.2210/rcsb_pdb/goodsell-gallery-041 / CC BY 4.0 (cropped) - GPCRの
動きを 計算と 1分子で 見る: “Molecular dynamics algorithm” Knordlun / CC BY-SA 3.0 (cropped) - Related lab (薬理ゲノミクス・ゲノム創薬科学): “Rasyslami” The original uploader was (Automated conversion) at English Wikipedia. / CC BY-SA 3.0 (cropped)
- Related lab (代謝ゲノム薬学): “High Fibre Foods” formulatehealth / CC BY 2.0 (cropped)
- Related lab (ケミカルバイオロジー): “Chemical biology flowchart” Bread6 / CC0 (cropped)
- Related lab (臨床薬学教育): “Kommissionierroboter in der Apotheke der Universitätsklinik Münster” UKM Elisabeth Deiters-Keul / CC BY-SA 3.0 (cropped)
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