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Neuroscience and Cognitive Neurophysiology Lab
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The lab measures and manipulates brain circuits in monkeys to uncover the mechanisms of anxiety and motivation.
AboutAbout the lab
Decoding the brain mechanisms that regulate anxiety and conflict
The lab measures and manipulates brain circuits in primates, aiming to uncover how anxiety and conflict are appropriately regulated.
For the treatment of depression and anxiety disorders, behavioral changes produced by manipulating local neural circuits are drawing attention, but the brain regions and circuit mechanisms responsible for anxiety and decision-making are not yet well understood.
Using an approach-avoidance conflict task, which allows anxiety to be expressed numerically, in primates whose brain structure resembles that of humans, the lab is identifying neural circuits causally involved in value judgment.
The lab welcomes people who are interested in both basic neuroscience and cognitive neuroscience and want to explore causal relationships between the brain and behavior.
Key terms
- Approach-avoidance conflict task
- A task in which the subject chooses between options that carry both reward and punishment, allowing the strength of anxiety to be measured from behavior.
- Striatum
- A region deep within the cerebrum that is involved in motivation, decision-making, and movement.
- fMRI
- A method that detects changes in blood flow accompanying brain activity and visualizes which regions are active.
ResearchResearch themes
Anxiety, mood, motivation, and value judgment are processed by neural circuits running from the limbic system to the basal ganglia. By measuring and manipulating these circuits in macaque monkeys, the lab aims to elucidate and control the mechanisms of depression and anxiety disorders.
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MembersFaculty
- ProfessorKen-ichi Amemori
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Basal Ganglia Go and NoGo Pathways” Colder B / CC BY 4.0 (cropped)
- Brain circuits that shape anxiety and motivation: “Basal-ganglia-2” 作者不詳 / Public domain (cropped)
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