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Fundamental Hydrocarbon Chemistry Lab
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The lab develops molecules that respond to light and enzymes in order to detect cancer and deliver drugs.
AboutAbout the lab
Designing molecules for use in medicine and materials
The Fundamental Hydrocarbon Chemistry Lab works on methods for synthesizing heterocyclic compounds using transition metal complexes as catalysts, and on creating complexes with bent alkyne ligands.
The lab also develops functional molecules for medicine, including molecular machines that deliver drugs only to cells exposed to light, molecular probes that track enzyme activity and pH changes inside cells, and contrast agents for cancer.
Key terms
- Heterocyclic compound
- A compound that contains atoms other than carbon, such as nitrogen or oxygen, in its ring
- Molecular probe
- A marker molecule that signals changes inside cells, for example through light
- Photoacoustic
- Ultrasound waves emitted by a substance that has absorbed light. Used to produce images of the inside of the body
ResearchResearch themes
The lab develops functional molecules, ranging from organic synthesis using transition metal complexes to light-activated drug delivery, molecular probes, and contrast agents for cancer.
*Illustrative imageBuilding heterocycles with metal complexes
The lab is pioneering methods that use transition metal complexes to act on readily available starting materials, cleaving nitrogen–oxygen and carbon–carbon bonds, in order to synthesize heterocyclic compounds used in pharmaceuticals and luminescent materials.
*Illustrative imageDelivering drugs into cells with light
The lab has developed a method that uses molecular machines that move when exposed to light to deliver drugs that have difficulty entering cells, such as nucleic acid therapeutics, only to the cells that have been illuminated. It is now working on new molecular machines.
*Illustrative imageStimulus-responsive molecular probes
The lab develops molecular probes that can track enzyme activity and pH changes inside cells. It has also developed a molecular probe that detects aldehyde dehydrogenase, which is produced in large amounts in cancer stem cells.
*Illustrative imageContrast agents for cancer
The lab develops contrast agents containing dyes that emit fluorescence or photoacoustic waves when exposed to light. In collaboration with the Graduate School of Medicine and companies, it is developing contrast agents that can distinguish the enzyme activity and pH changes characteristic of cancerous sites.
MembersFaculty
- Associate ProfessorKoji Miki
- Assistant ProfessorMU Huiying
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Confocal micrograph of stained HeLa” Dedyseptiadi7 / CC BY-SA 4.0 (cropped)
- Building heterocycles with metal complexes: “Pyridine-3D-balls” Ben Mills / Public domain (cropped)
- Delivering drugs into cells with light: “Overcrowded alkane molecular motor” Kutay B. Sezginel / CC BY-SA 4.0 (cropped)
- Stimulus-responsive molecular probes: “1cw3” Deposition authors: Ni, L., Zhou, J., Hurley, T.D., Weiner, H.; visualization author: User:Astrojan / CC BY-SA 4.0 (cropped)
- Contrast agents for cancer: “Fluorescence microscopy of the DNA of the oral cancer cells” Korinna / CC BY 4.0 (cropped)
- Related lab (Materials Analytical Chemistry Lab): “Moseley Hall Chemistry Lab” Mbrickn / CC BY-SA 4.0 (cropped)
- Related lab (Reaction Engineering Lab): “Toyota Mirai fuel cell stack and hydrogen tank SAO” Mariordo (Mario Roberto Durán Ortiz) / CC BY-SA 4.0 (cropped)
- Related lab (Organic Molecular Transformation Lab): “Iron(III)-chloride-hexahydrate-sample” Benjah-bmm27 / Public domain (cropped)
- Related lab (Functional Solid State Chemistry Lab): “U.S. Department of Energy - Science - )” U.S. Department of Energy from United States / Public domain (cropped)
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