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Host Defense Information Science Lab
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A lab that explores how flavonoids, natural compounds, protect cells.
AboutAbout the lab
Uncovering the mechanisms that protect the body, starting from cells.
The Host Defense Information Science Lab studies the immune mechanisms that protect the body and the cell-protective effects of flavonoids, which are natural compounds.
On the lab's website, it is introduced under the name "Kawabe Lab."
Associate Professor Matsushima studied the mechanisms by which flavonoids protect cells.
Professor Kawabe is working to elucidate how flavonoids enhance innate immunity and help prevent pneumonia.
Professor Kawabe also studied the relationship between the immune response and the function of macrophages in engulfing and processing dead cells.
Professor Sato is working on research into genes that could serve as new therapeutic targets for lung cancer.
Key terms
- Flavonoids
- Natural functional compounds that can be obtained from vegetables and other foods, and that show various cell-protective effects
- Autophagy
- A mechanism in which cells enclose and break down their own components, and which is involved in protecting cells
- Innate immunity
- The body's inborn defense mechanisms against pathogens and other threats, carried out by neutrophils and alveolar macrophages
ResearchResearch themes
Using experiments with cultured cells and animals, the lab investigates host defense mechanisms that protect the body from external stress and pathogens. Taking the cell-protective effects of flavonoids, which are natural compounds, and genes that could serve as new therapeutic targets for lung cancer as clues, it aims to obtain findings that lead to disease prevention and treatment.
How Flavonoids Protect Cells
The lab studied the mechanism that produces the cell-protective effects of quercetin, a type of flavonoid. It showed that HO-1 induced by quercetin is involved in regulating selective autophagy, and also reported that a decrease in cholesterol in the cell membrane is essential for the activation of Nrf2 (Associate Professor Matsushima). It is now working to elucidate how flavonoids enhance innate immunity and help prevent pneumonia, which tends to become severe in older adults (Professor Kawabe).
Genes as Therapeutic Targets for Lung Cancer
As a candidate for a new therapeutic target in lung cancer, the lab has identified a phosphatase gene that negatively regulates the MAPK signaling pathway, which is involved in cell proliferation. It is investigating whether lung cancer can be treated by suppressing the function of this gene, together with the mechanism by which proliferation is suppressed (Professor Sato).
MembersFaculty
- ProfessorTsutomu Kawabe
- ProfessorMitsuo Sato
- Associate ProfessorMiyoko Matsushima
- Assistant ProfessorKazuhiro Matsuoka
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Tingible body macrophage” Arnold, Michael A.; Kahwash, Samir B. / CC BY 3.0 (cropped)
- Related lab (Biomolecular Information Science Lab): “Agilent 1200HPLC and 6130 MS” Nick Birse / CC BY-SA 4.0 (cropped)
- Related lab (Medical Functional Imaging Evaluation Lab): “A nuclear medicine machine is used for medical imaging in a hospital in North Carolina 04” Harrison Keely / CC BY 4.0 (cropped)
- Related lab (Biological Function Science Lab): “Spangdahlem physical therapy rehabilitates Airmen after injury (7270864)” U.S. Air Force photo by Staff Sgt. Chanceler Nardone / Public domain (cropped)
- Related lab (Cellular Genetics and Information Science Lab): “Test tubes in rack” J.N. Eskra / CC BY-SA 4.0 (cropped)
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