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Cellular Genetics and Information Science Lab
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A lab that investigates how leukemia develops and how to treat it by studying the genetic abnormalities behind the disease.
AboutAbout the lab
Approaching how leukemia develops through its genetic abnormalities.
The Cellular Genetics and Information Science Lab studies, at the molecular level, how hematologic malignancies such as acute leukemia arise.
Focusing mainly on acute lymphoblastic leukemia, the lab searches for genetic abnormalities in patient samples collected through nationwide collaborative studies.
The lab investigates why the genetic abnormalities it finds cause leukemia, using experiments such as introducing genes into cells.
The lab also searches among existing drugs for ones with antitumor activity that have been overlooked until now.
Key terms
- Hematologic malignancies
- Cancers of the cells that produce blood, including leukemia
- Fusion gene
- A gene formed when parts of two genes become joined together. It is one type of abnormality found in leukemia
- Transcription factor
- A protein that regulates the activity of other genes. MEF2D and PAX5 are examples
NewsLab news
View More ↗ResearchResearch themes
Many hematologic malignancies, including acute leukemia, are still difficult to cure, and there is a need to develop treatments that match the mechanisms of the disease. Focusing mainly on acute lymphoblastic leukemia, this lab works to clarify how the disease develops and to develop treatments, and it also searches existing drugs for ones with antitumor activity.
*Illustrative imageComprehensive analysis of leukemia genes
RNA sequencing of samples from patients aged 15 to 24 with acute lymphoblastic leukemia, collected in a multicenter collaborative clinical study, led the lab to discover that DUX4, ZNF384, and MEF2D fusion genes are found at high frequency (2016 paper). The lab also showed a tendency for prognosis to differ depending on the type of fusion gene.
*Illustrative imageMEF2D fusion genes and the onset of leukemia
The lab is investigating why the new genetic abnormalities it discovered cause leukemia. For MEF2D fusion genes, the lab proposed a model in which the fusion protein is produced in large amounts and suppresses the function of PAX5, a transcription factor involved in B-cell differentiation, leading to leukemia (2019 paper).
MembersFaculty
Members of the Cellular Genetics and Information Science Lab consist of faculty, professors emeriti, and students in the Master's program and the undergraduate program.As of 2025
- ProfessorFumihiko Fumihiko
- Assistant ProfessorMina Nora
- Assistant ProfessorShuichi Okamoto
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Test tubes in rack” J.N. Eskra / CC BY-SA 4.0 (cropped)
- Comprehensive analysis of leukemia genes: “Blood Smear Unstained (NIH BioArt 675)” NIH NIAID Ryan Kissinger / Public domain (cropped)
- MEF2D fusion genes and the onset of leukemia: “Transcription factor Creb PDB 1dh3” Emw / CC BY-SA 3.0 (cropped)
- Related lab (Real-World Information, Health and Medicine Lab): “COMPUTER ROOM DISCHARGE” Keith4048 / Public domain (cropped)
- Related lab (Biomolecular Information Science Lab): “Agilent 1200HPLC and 6130 MS” Nick Birse / CC BY-SA 4.0 (cropped)
- Related lab (Pathophysiology and Information Science Lab): “Lab tech at microscope 2” Mike Blyth / CC BY 3.0 (cropped)
- Related lab (Host Defense Information Science Lab): “Tingible body macrophage” Arnold, Michael A.; Kahwash, Samir B. / CC BY 3.0 (cropped)
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