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Health and Sports Medicine Lab
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A lab that investigates insulin resistance from the perspectives of exercise and nutrition.
AboutAbout the lab
Aiming to prevent lifestyle-related diseases through exercise and nutrition
The Health and Sports Medicine Lab studies the mechanisms by which insulin resistance develops, as well as countermeasures against it.
Insulin resistance is a major pathological condition underlying lifestyle-related diseases such as obesity, diabetes, and hypertension, and is also thought to be a cause of aging.
The lab focuses in particular on preventive interventions through exercise and nutrition therapy, and conducts studies in humans, animal experiments, and molecular biological investigations.
In recent years, the lab has also begun studying how the brain (the central nervous system) regulates glucose and energy metabolism.
Key terms
- Insulin resistance
- A condition in which insulin becomes less effective. It is a major pathological condition underlying lifestyle-related diseases and is also thought to be a cause of aging.
- Sarcopenia
- The loss of skeletal muscle with aging. It is a cause of physical frailty.
- PTP1B
- A regulator of insulin, leptin, and inflammation. The lab focuses on it in its research on glucose and energy balance.
ResearchResearch themes
The lab aims to clarify the mechanisms by which insulin resistance develops and how to counter it, and thereby contribute to preventing the onset and halting the progression of lifestyle-related diseases. Focusing on preventive interventions through exercise and nutrition therapy, it investigates them through studies in humans, animal experiments, and molecular biological investigations.
*Illustrative imageBasic and clinical studies of insulin resistance
The lab examines how insulin resistance affects glucose metabolism, skeletal muscle, and the brain. Insulin resistance is thought to be deeply involved in the pathology of sarcopenia and dementia, and the lab aims to identify appropriate ways to control it through exercise and nutrition.
*Illustrative imageRegulation of glucose and energy metabolism by the brain
The lab studies the mechanisms in the brain (the central nervous system) that regulate energy balance. Focusing on PTP1B, a regulator of insulin, leptin, and inflammation, it is advancing this research using a variety of genetically modified mice.
MembersFaculty
- ProfessorTeruhiko Koike
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Blood Glucose Testing - Kolkata” Biswarup Ganguly / CC BY 3.0 (cropped)
- Basic and clinical studies of insulin resistance: “Capteur de glycémie pour personnes diabétiques” Celeda / CC BY-SA 4.0 (cropped)
- Regulation of glucose and energy metabolism by the brain: “Leptin” Vossman / CC BY-SA 3.0 (cropped)
- Related lab (分子細胞薬理学【薬理学】): “Microscope à fluorescence (Ifremer )” Olivier Dugornay / CC BY 4.0 (cropped)
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