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Urology Lab
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A urology lab studying cancers of the urinary tract and male genital tract, as well as lower urinary tract function.
AboutAbout the lab
Everything for the patients
The Urology Lab engages in clinical care and research on diseases of organs including the kidneys, adrenal glands, ureters, bladder, prostate, urethra, penis, and testes.
Its research centers on malignant tumors and lower urinary tract function, spanning basic, translational, and clinical research.
The lab also carries out clinical research that crosses the boundary between the university hospital and affiliated hospitals, sharing clinical databases and more through working groups organized by specialty area.
The lab is run under the motto "Everything for the patients."
Key terms
- Gleason score
- An indicator of the degree of cell differentiation in prostate cancer and an important guide to malignancy. It is determined by visual examination
- Liquid biopsy
- A test that examines urine samples to detect cancer-specific changes in a way that places little burden on the body
- Immune checkpoint inhibitors
- Drugs given as systemic treatment for metastatic urothelial carcinoma
- Cancer-associated fibroblasts
- Those carrying a molecule called Meflin are regarded as a marker of "cancer-suppressive fibroblasts"
ResearchResearch themes
The Urology Lab conducts basic, translational, and clinical research centered on malignant tumors and lower urinary tract function. In prostate cancer, it aims to optimize treatment through genetic analysis; in bladder cancer, it aims to develop new treatments and urine-based tests.
*Illustrative imageGenetic analysis of metastatic prostate cancer
Using biopsy tissue taken at diagnosis from patients with metastatic prostate cancer, the lab performs whole-exome sequencing and gene expression analysis. In collaboration with universities across Japan, it aims to identify biomarkers for optimizing treatment.
*Illustrative imageGenetic classification of prostate cancer differentiation
The Gleason score, an indicator of the degree of differentiation in prostate cancer, is determined by visual examination, so variation between observers and institutions is a problem. Using single-cell sequencing and spatial gene expression analysis, the lab aims to build a classification that also takes cell characteristics into account.
*Illustrative imageNew treatment for metastatic bladder cancer
In metastatic urothelial carcinoma, the response rate to immune checkpoint inhibitors is insufficient. Under the guidance of the Department of Tumor Pathology, the lab found that pretreatment with a drug that induces cancer-associated fibroblasts highly expressing Meflin in bladder cancer enhances the effect of these inhibitors, and is preparing a clinical trial.
*Illustrative imageUrine-based liquid biopsy for bladder cancer
No urine-based biomarker for bladder cancer yet outperforms urine cytology. By closely examining surgical specimens and identifying gene mutations that tend to occur in cancerous regions, the lab aims to develop a test that detects cancer-specific changes in urine.
MembersFaculty
The members of the Urology Lab consist of faculty members, specialty residents, staff physicians/graduate students, and graduate students.As of 2026
- ProfessorShusuke Akamatsu
- Associate ProfessorKenji Zennami
- LecturerShohei Ishida
- Hospital LecturerTomokazu Kimura
- Hospital LecturerTomoyasu Sano
- Assistant ProfessorKazuna Matsuo
- Assistant ProfessorSatoshi Inoue
- Assistant ProfessorTakeshi Namekawa
- Assistant ProfessorYuta Sano
- Assistant ProfessorYuji Naito
- Hospital Assistant ProfessorKyosuke Hattori
- Assistant ProfessorJun Nagayama
- Assistant ProfessorMasahiro Takikawa
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Operating-room 2” 연세건우병원 / CC BY 4.0 (cropped)
- Genetic analysis of metastatic prostate cancer: “Exome Sequencing workflow 1b” SarahKusala / CC BY 3.0 (cropped)
- Genetic classification of prostate cancer differentiation: “DNA microarray chip” ErikAbner / CC BY 4.0 (cropped)
- New treatment for metastatic bladder cancer: “Drug vials ( )” Lee Haywood from Wollaton, Nottingham, England / CC BY-SA 2.0 (cropped)
- Urine-based liquid biopsy for bladder cancer: “Human urine sample in a glass - 20080606” Katarighe. / CC BY-SA 3.0 (cropped)
- Related lab (Data-Driven Biology Lab): “Fluorescence.microscope3” Bioguy10 / CC0 (cropped)
- Related lab (Health and Sports Medicine Lab): “Blood Glucose Testing - Kolkata” Biswarup Ganguly / CC BY 3.0 (cropped)
- Related lab (Molecular Biology (Biochemistry I) Lab): “Smartphone colorimetry – 96-well microplate with serial dilutions of coloured solutions” Mdc-science / CC BY-SA 4.0 (cropped)
- Related lab (Gastroenterological Surgery Lab): “Quirófano robótico” Hospitalhoms / CC BY-SA 4.0 (cropped)
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