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Pathology and Biological Responses Lab (Pathology I)
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A pathology lab that investigates the role of oxidative stress from the cellular level to the whole organism.
AboutAbout the lab
Tracing oxidative stress from cells to whole organisms.
The Pathology and Biological Responses Lab studies broadly and in depth what oxidative stress means for living organisms, from the cellular level to the level of the human individual.
While valuing the morphological approach that is characteristic of pathology, the lab carries out its research using methods from genetics, cell engineering, and genetic engineering.
Students can gain broad morphological knowledge needed to analyze genetically modified animals, and those with an MD (medical doctor) degree can, if they wish, also receive basic training as a pathologist in parallel.
The lab welcomes students with a deep interest in oxidative stress, regardless of their original field.
Key terms
- Oxidative stress
- Oxidative damage caused by reactive oxygen species. It is involved in conditions such as carcinogenesis, arteriosclerosis, and diabetes
- Oxygenomics
- A concept proposed by this lab: the comprehensive analysis of sites in the genome where oxidative damage is likely to occur
- Low-temperature plasma
- Plasma, the fourth physical state of matter after solid, liquid, and gas, at temperatures close to body temperature
ResearchResearch themes
The lab aims to investigate the biological significance of oxidative stress from the cellular level to the level of the human individual. Its work covers iron-mediated carcinogenesis, the toxicity of fibrous inorganic materials, markers of oxidative stress, and medical applications of low-temperature plasma.
*Illustrative imageMechanisms of Carcinogenesis Caused by Reactive Oxygen Species
The lab has analyzed a renal carcinogenesis model induced by ferric nitrilotriacetate for many years. It proposed oxygenomics, which examines the sites in the genome where oxidative damage is likely to occur, and is also exploring approaches to cancer prevention.
*Illustrative imageToxicity of Asbestos and Other Fibrous Materials
The lab works to elucidate the pathogenesis of asbestos-related disease, and has shown that chrysotile (white asbestos), although it contains no iron, also accumulates iron in the body and is extremely carcinogenic. It also evaluates the toxicity and carcinogenicity of carbon nanotubes.
*Illustrative imageDevelopment of Oxidative Stress Markers
Building on the results of its carcinogenesis research and other work, the lab develops new markers of oxidative stress. In a collaborative project, it is also developing a method to visualize catalytic ferrous iron, which is the starting point of the Fenton reaction.
*Illustrative imageMedical Applications of Low-Temperature Plasma
The lab has worked on this since 2012 through medical-engineering collaboration. It has become clear that low-temperature plasma can be used to deliberately apply oxidative stress at various levels, and the lab aims to apply it to sterilization, hemostasis, cancer treatment, and more.
MembersFaculty
The members of the Pathology and Biological Responses Lab are faculty (Professor, Associate Professor, Lecturer, Assistant Professor).
- ProfessorShinya Toyokuni
- Associate ProfessorYasumasa Okazaki
- LecturerShinya Akatsuka
- Assistant ProfessorDaisha Motooka
- Assistant ProfessorYuki Ohara
- Assistant ProfessorYingyi Kong
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Scientist are at the Biomedical Research Laboratory Center 04” Oloyedegk / CC BY-SA 4.0 (cropped)
- Mechanisms of Carcinogenesis Caused by Reactive Oxygen Species: “Iron(II) oxide” http://en.wikipedia.org/w/index.php?title=User:Fuzic&action=edit / Public domain (cropped)
- Toxicity of Asbestos and Other Fibrous Materials: “Asbestos fibres” Aram Dulyan (User:Aramgutang) / Public domain (cropped)
- Development of Oxidative Stress Markers: “SK8-18-2 human derived cells, fluorescence microscopy ( )” ZEISS Microscopy from Germany / CC BY 2.0 (cropped)
- Medical Applications of Low-Temperature Plasma: “Plasma Trees” Themarnicle / CC BY 4.0 (cropped)
- Related lab (腫瘍病理学／分子病理学【病理学第二】): “Pathologists looking into microscopes (1)” Linda Bartlett (Photographer) / Public domain (cropped)
- Related lab (血液・腫瘍内科学): “FACS-toestel” Biol / Public domain (cropped)
- Related lab (機能組織学【解剖学第二】): “The neuroscience imaging lab” Rosario Gulino / CC BY-SA 4.0 (cropped)
- Related lab (統合生理学【生理学第二】): “Clinical thermometer 38.7” Menchi / CC BY-SA 3.0 (cropped)
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