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Tumor Pathology / Molecular Pathology Lab (Pathology II)
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A pathology lab that explores the nature of cancer and fibrotic diseases through the stroma and molecular analysis.
AboutAbout the lab
Training pathologists and pursuing original pathology research.
The Tumor Pathology / Molecular Pathology Lab aims to train board-certified pathologists and to develop pathology research that is as original as possible.
Through graduate research, the lab aims to train pathologists who can set their own morphology-based research questions.
Centered on functional analysis of molecules and morphology, the lab conducts research with members from diverse backgrounds.
The training of board-certified pathologists is supported by the Division of Pathology at Nagoya University Hospital and affiliated hospitals.
Key terms
- Stroma
- The region of cancer tissue other than epithelial cells, where cells such as cancer-associated fibroblasts increase
- Fibroblast
- A type of cell essential for maintaining tissue structure, now also known to function as a niche for tissue stem cells
- Mechanopathology
- A perspective for understanding human disease conditions in terms of mechanical stress and tissue stiffness
NewsLab news
A paper reports that complement C3 locally in tumors promotes the response to immune checkpoint inhibitors
A School of Medicine student won an Excellence Award at the 22nd Japanese Society of Pathology Conference
A School of Medicine student won an Outstanding Presentation Award in the undergraduate poster session at the Annual Meeting of the Japanese Society of Pathology
A paper reports on the relationship between fibroblasts and Meflin in triple-negative breast cancer
A paper by a lecturer in the lab and colleagues identifies Meflin as a marker of meningeal cells and reports its relationship to meningioma
ResearchResearch themes
Centered on functional analysis of molecules and morphology, the lab seeks to understand the nature of cancer and fibrotic diseases. It focuses on the diversity of the cells that make up the stroma and on the nature of fibroblasts.
*Illustrative imageDiversity of the Cells That Form the Cancer Stroma
Fibroblasts increase in the cancer stroma, and their functions are diverse. The lab identified Meflin as a marker of fibroblasts that play important roles in suppressing cancer and repairing damaged tissue.
*Illustrative imageThe Nature of Fibroblasts and Mechanopathology
Much about the nature of fibroblasts remains unclear, and the lab plans to approach it mainly through morphological pathology. Incorporating the perspective of mechanopathology, it found in mice that altering the properties of fibroblasts reduces the stiffness of the stroma in pancreatic cancer and improves drug delivery.
MembersFaculty
The members of the Tumor Pathology / Molecular Pathology Lab are faculty, graduate students, collaborators including graduate students affiliated with other departments, and department staff such as technical staff and administrative staff.As of 2026
- ProfessorAtsushi Enomoto
- LecturerYukihiro Shiraki
- Project LecturerShimpei Kubota
- Assistant ProfessorNobutoshi Esaki
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Pathologists looking into microscopes (1)” Linda Bartlett (Photographer) / Public domain (cropped)
- Diversity of the Cells That Form the Cancer Stroma: “Microtubules in Primary Mouse Embryonic Fibroblasts” Howard Vindin / CC BY 4.0 (cropped)
- The Nature of Fibroblasts and Mechanopathology: “Scanning electron microscopy of collagen fibers” NIH Image Gallery / CC BY-SA 4.0 (cropped)
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- Related lab (Pathology and Biological Responses Lab (Pathology I)): “Scientist are at the Biomedical Research Laboratory Center 04” Oloyedegk / CC BY-SA 4.0 (cropped)
- Related lab (Cancer Pharmacotherapy Lab (Hospital Department of Chemotherapy)): “Aviano Airmen share the love (7051294)” U.S. Air Force photo by Senior Airman Brooke Keisler / Public domain (cropped)
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