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Deguchi Lab
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A lab that creates new drugs and diagnostics from the environment surrounding cancer.
AboutAbout the lab
Developing drugs that stop metastasis.
The Deguchi Lab develops therapeutic drugs that prevent or suppress cancer metastasis.
Cancer is the leading cause of death in Japan, and metastasis to distant organs is thought to be its main cause.
Through basic research, the lab investigates the mechanisms of the microenvironment that forms around cancer. Based on the clues found there, it develops new forms of drugs such as small molecule compounds, multivalent peptides, and antibodies.
At the same time, it also works on developing diagnostics for stratifying patients, as well as validation models that assume actual clinical settings.
Key terms
- Tumor microenvironment
- The environment that forms around cancer cells, made up of blood vessels, immune cells, fibroblasts, and other components. It influences how readily the cancer progresses
- Modality
- The types of forms a drug can take, such as small molecule compounds, antibodies, and peptides
- Medical regulatory science
- A field that considers how to evaluate new medical technologies on the basis of scientific evidence and deliver them to society
ResearchResearch themes
The Deguchi Lab develops new modalities such as small molecule compounds, multivalent peptides, and antibodies, based on clues found through basic research into how the tumor microenvironment forms. To turn clues from basic research into drugs and deliver them to society, challenges at each stage of development must be considered from many angles and evaluated against appropriate criteria. For this reason, the lab makes the concept of medical regulatory science a pillar of its work.
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MembersFaculty
The members of the Deguchi Lab consist of faculty and doctoral students.
- ProfessorAtsuko Deguchi
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “IBC-HE” 藤澤孝志 / CC BY-SA 4.0 (cropped)
- Clues to stopping cancer metastasis: “Metastatic Melanoma Cells Nci-vol-9872-300” Julio C. Valencia / Public domain (cropped)
- Related lab (大和研究室): “Human induced pluripotent stem cell colony ( )” NIH Image Gallery from Bethesda, Maryland, USA / Public domain (cropped)
- Related lab (南部研究室): “CT Scanner (NIH BioArt )” NIAID Ryan Kissinger / Public domain (cropped)
- Related lab (正宗研究室): “Endoscopy” Linda Bartlett / Public domain (cropped)
- Related lab (田村研究室): “Cerebral hemisphere - 01” Polygon data were generated by Database Center for Life Science (DBCLS) / CC BY-SA 2.1 jp (cropped)
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