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Shichino Lab
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The lab explores the mechanisms of cancer immunity and fibrosis through single-cell gene analysis.
AboutAbout the lab
Approaching disease mechanisms through single-cell analysis
The Shichino Lab studies the mechanisms of diseases such as cancer, pulmonary fibrosis, and amyotrophic lateral sclerosis (ALS) using methods including single-cell RNA-seq analysis.
In cancer immunity, the lab develops methods for analyzing T cell receptors (TCRs), aiming to enable early identification of patients who respond to ICIs and to develop cell therapies that use TCRs.
In ALS, the lab uses iPS cells derived from ALS patients to investigate the relationship between an individual's genetic background and motor neuron damage.
Associate Professor Shigeyuki Shichino joined the Faculty of Information Science and Technology, Department of Information Science and Technology, in April 2026 from the Research Institute for Biomedical Sciences.
Key terms
- Single-cell RNA-seq
- An analysis method that separates cells one by one and reads the genes (RNA) active in each cell.
- T cell receptor
- A molecule on the surface of T cells. It determines what the T cell reacts to (reaction specificity).
- ICI
- Immune checkpoint inhibitor. A drug that releases the brakes that suppress the immune response against cancer.
- Pulmonary fibrosis
- A serious condition that arises in association with various interstitial lung diseases.
ResearchResearch themes
The Shichino Lab investigates the cellular and molecular mechanisms involved in cancer immunity, ALS, and pulmonary fibrosis using methods such as single-cell omics analysis. In cancer immunity, it aims to develop ways to identify ICI responders and new cell therapies that use TCRs.
*Illustrative imageAnalysis of T cell receptors in cancer immunity
CD8+ T cells are one of the central players in cancer immunity. The lab develops methods for analyzing T cell receptors (TCRs), which determine what these cells react to. By rapidly identifying TCRs that react strongly to cancer, the lab aims to develop TCR-T cell therapy.
*Illustrative imageElucidating the genetic mechanisms of ALS
The lab investigates how an individual's genetic background relates to the mechanisms leading to motor neuron damage in ALS. Using single-cell RNA-seq data from several dozen ALS patient-derived iPS cell lines and interventions in thousands of genes through low-cost single-cell Perturb-seq, it aims to clarify causal relationships.
*Illustrative imageCellular and molecular basis of pulmonary fibrosis
The lab uses its own highly sensitive single-cell omics technology, mouse disease models, and clinical specimens from collaborators as well as pig lung disease models. It aims to identify the cells and molecules that contribute to the development of pulmonary fibrosis.
MembersFaculty
- Associate ProfessorShigeyuki Shichino
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “PMC4710586 ehp.124-A13.g002” Arnold C / CC0 (cropped)
- Analysis of T cell receptors in cancer immunity: “Healthy Human T Cell” NIAID/NIH / Public domain (cropped)
- Elucidating the genetic mechanisms of ALS: “Human induced pluripotent stem cell colony ( )” NIH Image Gallery from Bethesda, Maryland, USA / Public domain (cropped)
- Cellular and molecular basis of pulmonary fibrosis: “Srifhistology3” Mutleysmith / CC BY-SA 4.0 (cropped)
- Related lab (諸橋研究室): “Arabidopsis thaliana” Original uploader was Brona at en.wikipedia. User:Roepers at nl.wikipedia / CC BY-SA 3.0 (cropped)
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