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Hagiwara Lab
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A lab that explores how the brain works and what causes brain diseases, using synapses as a clue.

AboutAbout the lab
Understanding the brain, starting from the synapse.
The Hagiwara Lab analyzes the morphology and physiological functions of neural networks, centered on synapses, to understand the many functions of the brain.
Synapses are the adhesive junctions connecting neurons, and are considered the basic units that support brain function.
Through this research, the lab aims to contribute to elucidating the causes of neuropsychiatric disorders and developing treatments for them.
The lab's research rests on three pillars: morphological analysis, development of novel optogenetic tools and their application to behavioral experiments, and observation by electron microscopy.
Key terms
- Synapse
- An adhesive junction connecting neurons. Considered the basic unit of information transmission that supports brain function.
- Optogenetics
- A method that uses light-control tools to analyze brain function, examining the function of neural circuits through the behavior of mice under light stimulation.
- Electron microscope
- A microscope required to observe the structure of synapses, which are extremely small, on the nanometer scale.
NewsLab news
A paper on CAST deficiency in the presynapse was accepted by Biological and Pharmaceutical Bulletin
A fourth-year undergraduate and a master's student won a poster award at the Parallel Brain public symposium
A student won an Excellent Poster Award at the 3rd Parallel Brain Symposium
ResearchResearch themes
The brain receives a wide variety of external stimuli, integrates that information, and outputs it as behavior. The lab focuses on the synapse, the basic unit of information transmission, and investigates the morphology and physiological functions of neural networks using morphological analysis, optogenetics, and electron microscopy.
*Illustrative imageMorphological analysis of neurons and synapses
Using various genetically modified mice, the lab observes brain structure and the localization of functional molecules with methods such as immunohistochemistry, and analyzes neurodegeneration and abnormalities in transmission mechanisms. The lab has also established methods for observing neural circuits in the hypothalamus and amygdala, and will apply them to behavioral analysis in mice.
*Illustrative imageDeveloping new optogenetic tools
For a new light-control tool developed in collaboration with the Otsuka Lab at the University of Yamanashi, the lab verifies its localization within cells through morphological analysis. The tool will also be applied to analyzing brain function, clarifying neural circuits and their functions through behavioral experiments on mice under light stimulation.
*Illustrative imageThe fine structure of synapses seen with electron microscopy
Synapses are extremely small structures on the nanometer scale, so electron microscopy is required to observe them. The lab analyzes neural circuits and synaptic structure using images obtained through collaborations with the Fukazawa Lab at the University of Fukui, the National Institute for Physiological Sciences, and the Advanced Imaging Research Center at Kurume University.
MembersFaculty
The Hagiwara Lab consists of faculty members and master's and undergraduate students.As of 2026
- Associate ProfessorAkari Hagiwara
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Synapse neuro-neuronale” Savant-fou / CC BY-SA 3.0 (cropped)
- Morphological analysis of neurons and synapses: “Layer V Pyramidal cell from mouse visual cortex” Quorumetrix / CC BY-SA 4.0 (cropped)
- Developing new optogenetic tools: “STAT Optogenetics MIT Handout” statenews website hayadan website / CC BY 2.5 (cropped)
- The fine structure of synapses seen with electron microscopy: “Scanning electron microscope - UFCH JH (2020) 01” Tadeáš Bednarz / CC BY-SA 4.0 (cropped)
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