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Takahashi Lab
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A drug discovery chemistry lab that creates new medicines by focusing on their three-dimensional structures.
AboutAbout the lab
New medicines, created from three-dimensional structure.
The Takahashi Lab studies medicinal chemistry for drug discovery, creating new medicines by focusing on the three-dimensional shapes of drug molecules.
Regarding the three-dimensional structure of drugs as key to pharmacological activity, the lab analyzes stereochemistry from the perspective of axial chirality.
Using the power of organic chemistry, it also tackles themes directly tied to clinical practice, such as drug metabolism and interactions.
On the university's website, the lab is introduced as a "Drug Discovery Chemistry and Clinical Pharmaceutical Chemistry" lab in the Department of Pharmacy, and as a "Medicinal Chemistry" lab in the Department of Pharmaceutical Sciences of the Graduate School of Pharmaceutical Sciences.
Key terms
- Axial chirality
- Chirality that arises, even without an asymmetric carbon, from differences in the spatial arrangement around a molecular axis.
- Chiral
- The property of a molecule that cannot be superimposed on its mirror image. It is often compared to the relationship between the right and left hands.
- Stereochemistry
- The field that deals with the orientations and shapes in which atoms are arranged within a molecule.
ResearchResearch themes
The lab conducts research in drug discovery chemistry, using the three-dimensional structures of drugs as a clue to create new medicines. The page for the Department of Pharmaceutical Sciences lists example themes: creating molecules that are chiral without having an asymmetric carbon, creating drug candidate compounds with a seven-membered ring, and developing a treatment for Menkes disease.
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MembersFaculty
- ProfessorHideyo Takahashi
VoicesStudent voices
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Write a lab reviewAnonymous · Your draft is saved if you stopRelatedLabs similar to Takahashi Lab
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Shimada LabFaculty of Pharmaceutical Sciences, Department of PharmacyClinical pharmaceutical sciencesThe information on this page is compiled by the LabLog team from the lab's public information and interviews. For corrections or removal requests, please contact LabLog, not the lab.
Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Inside the Medicinal Chemistry Lab ( )” National Center for Advancing Translational Sciences from Bethesda, MD / Public domain (cropped)
- Drugs created from axial chirality: “XBio illustration – Small Molecule Drug Screen” explorebiology / CC BY 4.0 (cropped)
- Related lab (Hada Lab): “Maou” Hanabishi / CC BY-SA 3.0 (cropped)
- Related lab (Sakurai Lab): “Tula Pharmaceutical Factory 04” Пресс-центр Правительства Тульской области. / CC BY 4.0 (cropped)
- Related lab (Mano Lab): “Hospital pharmacy, 1970s ( )” University of Liverpool Faculty of Health & Life Sciences from Liverpool, United Kingdom / CC BY-SA 2.0 (cropped)
- Related lab (Shimada Lab): “Paxlovid pills close-up” Intellec7 / CC BY-SA 4.0 (cropped)
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