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Tsukimoto Lab
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The lab studies how cells respond to radiation, aiming to improve radiation therapy and reduce radiation-induced damage.
AboutAbout the lab
Exploring how cells respond to radiation
The Tsukimoto Lab studies how radiation affects living organisms, from a perspective unique to pharmaceutical sciences.
To improve radiation therapy, the lab works to uncover the mechanisms by which cancer cells respond to radiation.
The lab also conducts basic research toward developing radioprotectors that protect normal cells from radiation.
Key terms
- Purine-mediated intercellular signaling
- Communication between cells via purines, triggered by radiation. It is a new mechanism discovered by this lab.
- Radioprotector
- A drug that reduces radiation-induced damage. The aim is to protect normal cells from radiation.
- Radioresistance
- The property of cancer cells being resistant to radiation, so that radiation is less effective against them.
ResearchResearch themes
Protecting ourselves from the harm of radiation and using radiation in medicine both require elucidating the mechanisms by which radiation affects living organisms. The Tsukimoto Lab investigates these effects from a perspective unique to pharmaceutical sciences, and is exploring applications that would make radiation cancer therapy more effective.
*Illustrative imageIntercellular signaling triggered by radiation
While studying the effects of radiation on living organisms, the lab discovered a new mechanism called radiation-induced purine-mediated intercellular signaling. Based on this discovery, the lab is exploring applications that would make radiation cancer therapy more effective.
*Illustrative imageOsmotic pressure and radioresistance of cancer cells
The lab investigates how changes in osmotic pressure lead cancer cells to acquire radioresistance. This project aims to apply the findings to radiation therapy methods.
MembersFaculty
- ProfessorMitsutoshi Tsukimoto
- LecturerKazuki Kitabatake
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Radiation therapy for cancer” Jakembradford / CC BY-SA 4.0 (cropped)
- Intercellular signaling triggered by radiation: “Geiger counter 2” TimVickers / Public domain (cropped)
- Osmotic pressure and radioresistance of cancer cells: “Patient prepared for radiation therapy” Rhoda Baer (Photographer) / Public domain (cropped)
- Related lab (藤江研究室): “Blood vessels structure” Vslv / CC BY-SA 4.0 (cropped)
- Related lab (市原研究室): “Toxicology Research at FDA (NCTR - Biochemical Toxicology Division) ( )” The U.S. Food and Drug Administration / Public domain (cropped)
- Related lab (真野研究室): “Hospital pharmacy, 1970s ( )” University of Liverpool Faculty of Health & Life Sciences from Liverpool, United Kingdom / CC BY-SA 2.0 (cropped)
- Related lab (嶋田研究室): “Paxlovid pills close-up” Intellec7 / CC BY-SA 4.0 (cropped)
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