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Bioresource Management Lab
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A lab that accurately identifies pathogenic fungi by their morphology and genes.
AboutAbout the lab
Telling molds and yeasts apart, accurately.
The Bioresource Management Lab studies how to accurately identify molds and yeasts while managing strains of pathogenic fungi.
As part of strain management, the lab observes the morphology of pathogenic fungi, performs phylogenetic analysis, and examines differences within the same species.
It works on methods to rapidly identify species, both from cultured fungi and from uncultured samples.
Key terms
- Phylogenetic analysis
- A method that compares gene sequences and other data to determine how closely organisms are related and how they evolved
- Mass spectrometry
- A method that turns substances into charged particles and measures their mass to determine what is present and how much
- Primer
- A short piece of DNA that marks the region to be amplified when copying genes by PCR
NewsLab news
Associate Professor Yaguchi and colleagues publish the Dictionary of Medical Mycology, 3rd Edition
Press release published on a paper investigating how the fungi that cause mycetoma become resistant to drugs
ResearchResearch themes
As part of strain management, the lab studies morphological and phylogenetic analysis of pathogenic fungi, differences within a species (intraspecific polymorphism), and rapid identification from both cultured fungi and uncultured samples. Accurate and fast identification is needed to distinguish closely related fungi that respond differently to antifungal drugs, and to quickly pinpoint the cause of mold contamination in food.
*Illustrative imageIdentifying Aspergillus by mass spectrometry
Three species closely related to Aspergillus fumigatus respond differently to antifungal drugs, so accurate identification is necessary. The lab is developing, jointly with AIST (the National Institute of Advanced Industrial Science and Technology), a method to rapidly distinguish species and strains using mass spectrometry of ribosomal proteins.
*Illustrative imageRe-examining the characteristics of Candida species
After Candida intermedia, which had not been considered a pathogen, was found in patient specimens, the lab re-examined the characteristics of stored strains. It found that many strains can also grow at 35–37°C.
*Illustrative imageMating in Candida albicans
Mating in clinical isolates of Candida albicans has been thought to be rare. When the lab examined clinical isolates, it found that switching of the colony type involved in mating occurs more frequently than previously reported.
*Illustrative imageIdentifying molds that contaminate food
The lab studies how to identify heat-resistant molds so that the cause can be determined quickly when food is contaminated by mold. Based on differences in gene sequences, it designs primers that distinguish each species.
MembersFaculty
The Bioresource Management Lab's members consist of faculty, technical staff, technical assistants, and special collaborative researchers.As of 2026
- Associate ProfessorTakashi Yaguchi
- Assistant ProfessorSayaka Ban
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Four 3-day old Aspergillus colonies on a Petri dish” Adrian J. Hunter / CC BY-SA 3.0 (cropped)
- Identifying Aspergillus by mass spectrometry: “Liquid chromatograph with a mass spectrometer operating on the principle of flight time in combination with a quadrupole analyzer (qTOF) in CAFIA laboratory, Czech Republic” Sarka Na kopci / CC BY-SA 4.0 (cropped)
- Re-examining the characteristics of Candida species: “Gram positive yeast cells in Gram staining of culture” Ajay Kumar Chaurasiya / CC BY-SA 4.0 (cropped)
- Mating in Candida albicans: “Microscope view of Candida albicans 15” Korinna / CC BY 4.0 (cropped)
- Identifying molds that contaminate food: “A Moldy Loaf of Bread” Muldoonsamuel55 / CC0 (cropped)
- Related lab (カンジダフェノームプロジェクト): “Baking yeast cells under 40x microscope objective” ~delta / CC BY-SA 4.0 (cropped)
- Related lab (感染症制御プロジェクト): “Bacterial growth on blood agar” Ajay Kumar Chaurasiya / CC BY-SA 4.0 (cropped)
- Related lab (感染応答プロジェクト): “Influenza A Virus (H1N1)-1” NIH Image Gallery / Public domain (cropped)
- Related lab (臨床感染症プロジェクト): “Growth inhibition zone of Aspergillus” Atalyssa / CC BY 4.0 (cropped)
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