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Next-Generation Disaster Therapeutics Lab
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A lab that studies immune epigenomics and disaster medicine through two teams.
AboutAbout the lab
Immunology research and disaster preparedness as two driving forces
The Next-Generation Disaster Therapeutics Lab (Onodera Lab) pursues two lines of work: epigenome research on T cells and research on preparing for disasters.
The lab examines the T cell epigenome, focusing on enzymes that modify histones and on TET, an enzyme that oxidizes methyl groups on DNA.
It also looks at the chronic phase after a disaster and conducts basic research that can lead to measures against lifestyle-related diseases and infectious diseases.
The immunology team consists mainly of graduate students, and the disaster research team mainly of medical students.
Key terms
- Epigenome
- A system of marks that switch gene activity on and off without changing the DNA sequence.
- NKT cells
- Immune cells that have properties of both T cells and NK cells. They are also involved in attacking cancer cells.
- Bioinformatics
- A field that analyzes large amounts of genetic data using computers and programs.
NewsLab news
A student received a Scholarship Encouragement Award at Chiba BCRC
The lab received a Special Award at the Disaster Prevention and Mitigation Sustainability Grand Prize
An undergraduate student received a Poster Excellence Award at the Summer Retreat of the Eastern Japan Consortium for Training Physician-Scientists
Prof. Onodera received the Chiba Social Medicine Award in the Advanced category
A paper on TET and TDG has been published
ResearchResearch themes
The lab studies the T cell epigenome, focusing on analysis of histone-modifying enzymes and TET enzymes. It also conducts basic research to protect health after disasters and collaborates with researchers in other fields.
*Illustrative imageEpigenomics of iPS-NKT Cell Immunotherapy
The lab focuses on the fact that immune abnormalities caused by the loss of epigenome-related enzymes can sometimes work in a beneficial direction, such as by activating antitumor immunity. It participates in the clinical trial of iPS cell-derived NKT cells under way at Chiba University Hospital and works on developing new antitumor immunotherapy by manipulating epigenome-related genes.
*Illustrative imageAging and Abnormal Immune Cells
In humans, mutations in the TET2 gene are known to raise the risk of myeloproliferative neoplasms and coronary artery disease. Because the mechanism is still unknown, the lab uses mouse models and human clinical samples to analyze how aging, epigenetic abnormalities, and disease are related.
*Illustrative imageEpigenome Bioinformatics
In addition to standard next-generation sequencing analysis methods, the lab uses its own tools and computational methods to take on unsolved questions about the epigenome. It is particularly interested in the spatial relationships and interactions among epigenetic modifications.
*Illustrative imageBig Data for Disaster Medicine
Aiming at applications in disaster medicine, the lab analyzes meteorological data and links it with health data, using data published by government ministries and agencies. It also analyzes disaster-related data jointly with the Chiba City Fire Department.
MembersFaculty
The members of the Onodera Lab consist of faculty, visiting faculty, visiting researchers, research collaborators, technical assistants, graduate students, and medical students.As of 2026
- ProfessorAtsushi Onodera
- Project Assistant ProfessorTomohiro Ogino
- Project ProfessorHiroshi Asanuma
- Project ProfessorShintaro Maki
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Cryo-EM structure of the human nucleosome Histone H3.3 8KB5” Hirai S, Kujirai T, Akatsu M, Ogasawara M, Ehara H, Sekine SI, Ohkawa Y, Takizawa Y, Kurumizaka H / CC0 (cropped)
- Epigenomics of iPS-NKT Cell Immunotherapy: “Parkinson's induced pluripotent stem cell” US Department of Energy / Public domain (cropped)
- Aging and Abnormal Immune Cells: “Nucleated red blood cell with Cabot rings and basophilic granules” Makysm / CC0 (cropped)
- Epigenome Bioinformatics: “Integrated Genome Browser 9.1.0 showing chromosome 1 of the human genome assembly hg38” Aloraine / CC BY-SA 4.0 (cropped)
- Big Data for Disaster Medicine: “Himawari 8 Full Disk Earth” JMA / CC BY 4.0 (cropped)
- Related lab (Immune Cell Medicine Lab): “Лаборант готовит индивидуальный иммунологический препарат против рака из крови пациента” Иоанна Чернова / CC BY 4.0 (cropped)
- Related lab (Medical Informatics Lab): “Libre EHR - features” Nguedia Adele / CC BY-SA 4.0 (cropped)
- Related lab (Innovative Regenerative Medicine Lab): “Hematopoietic Stem Cell (NIH BioArt 200)” Courtesy of NIAID Ryan Kissinger / Public domain (cropped)
- Related lab (Molecular Oncology Lab): “ABI PRISM 3100 Genetic Analyzer 2” Mark Pellegrini / CC BY-SA 3.0 (cropped)
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