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Microbe and Immune Regulation Lab
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A lab that designs gut bacteria to build a body less prone to disease.
AboutAbout the lab
Tuning gut bacteria for a body less prone to disease.
The Microbe and Immune Regulation Lab, part of the Infection and Immunity division, studies the relationship between gut bacteria and our immune system.
Some people are infected by the same pathogen again and again, while others are never infected at all.
As a factor that determines this individual difference, the lab focuses on gut bacteria, which live in the gut from birth to death.
Because gut bacteria can be changed through things such as diet, the lab aims to build a body less prone to disease by optimizing them.
Key terms
- Gut bacteria
- Bacteria that live in the human intestine. Their composition changes with things such as diet and medication
- Germ-free mice
- Mice raised without any bacteria in their bodies. They are used to study the function of gut bacteria
- Metagenomic analysis
- A method that reads the DNA of the microbes present in a sample all together to find out which microbes are there
NewsLab news
Review by a graduate student and Associate Professor Goto published in Cell Mol Life Sci
Review by Associate Professor Goto and colleagues published in Rinsho Meneki Arerugi-ka (Clinical Immunology and Allergology), a Japanese journal
Graduate student wins Best Poster Award at the Global Network Forum on Infectious Disease Research
Review by Associate Professor Goto published in Igaku no Ayumi, a Japanese journal
Review by a graduate student and Associate Professor Goto published in a special issue of Jikken Igaku (Experimental Medicine), a Japanese journal
ResearchResearch themes
The lab holds the vision of making the body less prone to disease by optimizing gut bacteria. Its research is organized around three missions: finding gut bacteria that have beneficial effects on infections, elucidating how they work, and establishing technologies to design gut bacteria.
*Illustrative imageFinding gut bacteria that work against infections
Using anaerobic culture systems and germ-free mouse facilities, the lab identifies and isolates gut bacteria that have a protective effect against bacterial, fungal, and viral infections. It also develops technologies for prevention and treatment using the isolated bacteria and their metabolites.
*Illustrative imageElucidating how protection works
For gut bacteria with a protective effect, the lab clarifies the underlying mechanisms at the molecular, cellular, and whole-organism levels. It examines metabolites through metagenomic and metabolomic analysis, and also traces pathways that act through the activation of immune cells.
*Illustrative imageDesigning gut bacteria
The lab investigates how nutrients and antibiotics affect gut bacteria. It also works on strategies that use the CRISPR/Cas9 system to remove specific gut bacteria or genes, and on technologies to track the movement of bacteria.
MembersFaculty
The lab's members consist of faculty, project researchers, doctoral and master's students, undergraduate students, technical assistants, secretaries, and collaborating researchers.As of 2026
- Associate ProfessorYoshiyuki Goto
VoicesStudent voices
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Lacto2” Arunbiel / CC BY 4.0 (cropped)
- Finding gut bacteria that work against infections: “Anaerobic chamber ( )” Oak Ridge National Laboratory / CC BY 2.0 (cropped)
- Elucidating how protection works: “Biological Mass Spectrometry ( )” Oak Ridge National Laboratory / CC BY 2.0 (cropped)
- Designing gut bacteria: “Bacteria growth under the microscope - Two colonies of different bacteria” Korinna / CC BY 4.0 (cropped)
- Related lab (Microbial Genesis Lab): “Aspergillus fumigatus 01” CDC/Dr. Libero Ajello (PHIL #4297) / Public domain (cropped)
- Related lab (Animal Evolutionary Ecology Lab): “Hermit crab with a shell on a sandy bottom at night” Dmitry Domrin / CC BY 4.0 (cropped)
- Related lab (Cell Function Regulation Lab (Matsura-Itakura Lab)): “Gram positive budding yeast cells” Microrao / CC BY-SA 4.0 (cropped)
- Related lab (Evolutionary Diversity Lab): “Polished slice of petrified wood” Michael Gäbler / CC BY 3.0 (cropped)
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