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Microbial Genesis Lab
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A lab that reads pathogenic fungi through their genomes to explore ways of countering infections.
AboutAbout the lab
Taking on fungal infections through genomics.
The Microbial Genesis Lab, part of the Microbial Resources division, conducts research on the molecular basis of pathogenic fungi.
As the number of immunocompromised patients grows, infections caused by pathogenic fungi are becoming a serious public health problem.
The lab investigates the molecular mechanisms of infection and immunity: how fungi interact with the host immune system and how they evade it.
It also focuses on the mechanisms of resistance to antifungal drugs, which is becoming a serious clinical problem, and aims to develop treatment strategies based on genomic information.
Key terms
- Pathogenic fungi
- Molds and yeasts that cause infections in humans. They tend to be a problem for people with weakened immunity
- Drug resistance
- The acquisition by microbes of traits that make drugs less effective. It is spreading in antifungal drugs as well
- Genomics
- An approach to research that reads and compares the entire genetic information of organisms
NewsLab news
Paper by a Project Assistant Professor published in Microbiology Spectrum
Book by Professor Takahashi and colleagues, "PCR Typing and Genome Sequencing of Aspergillus fumigatus," published
Paper by a graduate student published in Microbiology Spectrum
Paper by a Project Assistant Professor published in Medical Mycology
ResearchResearch themes
The lab conducts research on the molecular basis of pathogenic fungi, aiming to elucidate infection immune responses, analyze the mechanisms by which fungi acquire drug resistance, and develop treatment strategies based on genomic information. Building on understanding at the molecular level, it works to bridge basic research and clinical application.
*Illustrative imageFungi, host immunity, and drug resistance
The lab aims to elucidate the molecular mechanisms of infection and immunity: how fungi interact with the host immune system and how they evade it. It also focuses on the mechanisms of resistance to antifungal drugs, which is a serious problem in clinical settings.
*Illustrative imageExploring diversity through genomics
Using genomic analysis with next-generation sequencing technologies, the lab works to identify the genetic diversity of pathogenic fungi, their evolutionary adaptation, and the gene networks involved in drug resistance.
MembersFaculty
The lab's members consist of faculty, postdoctoral researchers, graduate students, undergraduate students, and technical assistants.As of 2026
- ProfessorHiroki Takahashi
- Project Assistant ProfessorSaho Shibata
- Project Assistant ProfessorMomotake Uchida
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Report an errorAbout the images
The top and research theme images are illustrative and were not taken at the lab. They are cropped from Wikimedia Commons images. Cropped CC BY-SA images are provided under the same CC BY-SA license as the original (version shown on each line).
- Top image: “Aspergillus fumigatus 01” CDC/Dr. Libero Ajello (PHIL #4297) / Public domain (cropped)
- Fungi, host immunity, and drug resistance: “Candida albicans” Y tambe / CC BY-SA 3.0 (cropped)
- Exploring diversity through genomics: “Illumina NextSeq 500” Konrad Förstner / CC BY 2.0 (cropped)
- Related lab (Microbe and Immune Regulation Lab): “Lacto2” Arunbiel / CC BY 4.0 (cropped)
- Related lab (Epigenome Structure and Dynamics Lab (Osakabe Lab)): “Arabidopsis Thaliana planted in Laboratory” Jucember / CC BY-SA 3.0 (cropped)
- Related lab (Functional Ecology Lab): “Mountain Views, Rogue River-Siskiyou National Forest ( )” U.S. Forest Service- Pacific Northwest Region / Public domain (cropped)
- Related lab (Evolutionary Diversity Lab): “Polished slice of petrified wood” Michael Gäbler / CC BY 3.0 (cropped)
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